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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Dr
Nicola
West
Dry socket or alveolar osteitis
This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.
Dry socket is a common complication that can arise following the extraction of teeth by a dentist (General Dental Practitioner) or a specialist (Oral Surgery Specialist). Dry socket may be defined as the postoperative pain inside and around an extraction site, which increases in severity at any time between the first and third day after the extraction, accompanied by a partial or total disintegration of the blood clot within the tooth socket, with or without smelly breath (halitosis). Sufferers of dry socket usually need postoperative treatment to manage the condition.
The routine treatment for dry socket involves cleaning the area, under anaesthetic if necessary, packing it with a material to soothe the pain and if necessary using a suture (stitch) to hold the material in place while the socket heals. The material used to pack the socket plays an important role in soothing the pain and allowing healing to take place and researchers are always trying to find better more effective materials. A new material that can help the healing of tissue in the mouth following surgery is a product derived from the patients' own blood called PRGF (Plasma Rich in Growth Factors). It has been shown that PRGF enhances tissue healing and also improves the clinical outcomes of various surgical procedures by minimizing postoperative complications such as pain and inflammation/swelling. Venous blood is taken from the patient prior to surgery. The blood is then treated and heated to form a gel like structure which is then inserted at the treatment site. The PRGF then acts on the surrounding tissues to aid healing and regeneration.
The aim of this study is to investigate whether PRGF can reduce the pain and improve the healing of dry sockets in patients who have this condition following the extraction of a tooth when compared with a conventional treatment, Alvogyl®.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
2018 Results article in https://www.ncbi.nlm.nih.gov/pubmed/29382467 results
You can take part if:
You may not be able to take part if:
1. Breast-feeding Women who are breast–feeding.2. Disease2.1. Current or recurrent disease/dental pathology that could affect the assessments.2.2. Bleeding disorders.2.3. Immuno-compromised. 2.4. Current or relevant previous history of serious, severe or unstable physical or psychiatric illness, or any medical disorder that may require treatment or make the participant unlikely to fully complete the study, or any condition that presents undue risk from the study products or procedures.3. Allergy/Intolerance Known or suspected intolerance or sensitivity to the study materials (or closely related compounds) or any of their stated ingredients.4. Medication- Any medication which in the Investigators opinion may interfere with the study5. Clinical Study/Experimental Medication-Participation in another clinical study or receipt of an investigational drug within 10 days of the screening visit.6. Substance abuse Recent history of alcohol or other substance abuse.7. Personnel A member of the study site or a family relative. The study site for this protocol is the Clinical Trials Unit in the Bristol Dental School and Hospital. Employees of the Bristol Dental School and Hospital not associated with the Clinical Trials Unit are eligible to participate.8. Any patient who, in the judgement of the investigator, should not participate in the study.
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
This information has not yet been provided by the study team. You'll have an opportunity to discuss any risks and benefits that may be associated with this study prior to consenting to taking part.
Dr
Nicola
West
The study is sponsored by University of Bristol and funded by University of Bristol (UK).
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
You can print or share the study information with your GP/healthcare provider or contact the research team directly.
