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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Prof Jenny Myers
+44 (0)7747863985
jenny.myers@manchester.ac.uk


Prof Lucy Chappell
+44 (0)7973855025
lucy.chappell@kcl.ac.uk


More information about this study, what is involved and how to take part can be found on the study website.

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Be Part of Research - Trial Details - Blood pressure response assessment by pregnancy antihypertensive drug treatment
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Blood pressure response assessment by pregnancy antihypertensive drug treatment

Recruiting

Open to: Female

Age: Adult

London Manchester

Medical Conditions

Hypertension in pregnancy

This information is provided directly by researchers and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information.


Around one in ten women will have high blood pressure in pregnancy. Controlling high blood pressure in pregnancy with medicines is important to protect the health of the woman and her baby. There haven’t been enough studies to know which is the best blood pressure medicine to use in pregnancy. Previous studies have shown that the medicines commonly used do not work well in all women.
A large study (GIANT PANDA study) of the two main blood pressure medicines, called labetalol and nifedipine, aims to find out which one works best to treat high blood pressure, and to check if there are any effects on the baby. The researchers also want to see if there are differences in how well how these two medicines control blood pressure over a short time frame (12-24 hours), and to see if this helps us understand how these medicines work throughout pregnancy. They will also look at whether a woman’s ethnic background and kidney markers in her blood are related to how well blood pressure is controlled by these medicines. This may help us better understand why some blood pressure medicines do not work well in some pregnant women.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

16 May 2022 31 Dec 2024

Participants are provided with a monitor that automatically measures their blood pressure and heart rate every 30-60 minutes. They will be asked to wear the blood pressure monitor for 12-24 hours on up to three occasions during their pregnancy, coinciding with scheduled antenatal appointments where possible. Each time women complete this monitoring they will be asked to provide a urine and blood sample. Women will also be provided with a diary to record the times they take their blood pressure medicine, any side effects from the medicine, and the times they wake up and go to sleep during these monitoring periods.


Pregnant women aged 18 years and over with high blood pressure in pregnancy, who are participating in the GIANT PANDA study.

You can take part if:



You may not be able to take part if:


Diagnosis of preeclampsia


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • St Thomas' Hospital
    Westminster Bridge Road
    London
    SE1 7EH
  • St Mary's Hospital
    Oxford Road
    Manchester
    M13 9WL

Taking part will help the researchers to understand how best to treat women with high blood pressure in pregnancy. The possible disadvantages are the additional time spent with the study team and the inconvenience of having a blood test taken or wearing the blood pressure monitor for 24 hours. All women will continue to receive their usual NHS care during pregnancy while in this study.

Prof Lucy Chappell
+44 (0)7973855025
lucy.chappell@kcl.ac.uk


Prof Jenny Myers
+44 (0)7747863985
jenny.myers@manchester.ac.uk



More information about this study, what is involved and how to take part can be found on the study website.


The study is sponsored by University of Birmingham and funded by National Institute for Health Research.



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Read full details for Trial ID: ISRCTN87208603

Or CPMS 51935

Last updated 25 April 2024

This page is to help you find out about a research study and if you may be able to take part

You can print or share the study information with your GP/healthcare provider or contact the research team directly.   

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