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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Prof Carsten Flohr
+44 2071887188
Transfoods@kcl.ac.uk


Prof Carsten Flohr
+44 2071887188
Transfoods@kcl.ac.uk


Miss Preeti Khurana
+44 2071887188
Transfoods@kcl.ac.uk


Study Location:

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Be Part of Research - Trial Details - TRANS-FOODS: Reducing the risk of developing peanut allergy through the skin by improved understanding, modifying peanut snack production, and adjusting skincare practices.
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TRANS-FOODS: Reducing the risk of developing peanut allergy through the skin by improved understanding, modifying peanut snack production, and adjusting skincare practices.

Recruiting

Open to: All Genders

Age: Adult

London

Medical Conditions

Peanut allergy and atopic dermatitis

This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


Allergic diseases, including atopic eczema, and food allergies affect over a quarter of all children across Europe. The way the immune system responds to ingested foods are well-established, and regular eating of allergy-causing foods can prevent food allergies to a degree. However, recent research also shows that food allergies can develop through the skin, especially in the presence of dry skin and eczema. We do not fully understand how this happens at the moment.

This project aims to study the immune responses to peanut allergen in those with a skin barrier defect with and without skin massage.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

05 Apr 2024 31 Jul 2025

60 healthy adult volunteers and 60 adult volunteers with atopic dermatitis and dry skin will be asked to either massage, or not massage the skin after applying peanut extract twice daily for 4 weeks at home. Half of the participants will also apply a barrier enhancing cream 30 minutes before applying the peanut extract.

Samples of interstitial fluid (ISF) will be collected from the same location that the cream and peanut extracts are being applied and at another site that is remote to this site during a visit to King’s College London. The amount of water that evaporates from the skin will be measured with a small hand-held machine. A chamber will then be placed on your forearm and a small volume of water will be applied. A hand pump will be used to apply suction on your forearm for about 10 minutes at a pressure we know will not damage the skin. The suction will pull molecules called cytokines out of the skin and we will remove the liquid from the skin containing these cytokines using a plastic pipette. The extracted samples will be collected for analysis of the extracted chemicals.

Participation in this study will require presence in two extraction sessions with an interval of 4 weeks, each session will last for approximately 1 h.


Anyone without a history of peanut allergy​.
Anyone either with a history of dry skin/eczema or healthy skin​.
Anyone aged 18 years or over.

You can take part if:



You may not be able to take part if:


1. Patients unable to give informed consent.2. History of peanut allergy.3. Positive skin prick test to peanut (>0 mm).4. No regular consumption of peanut products.5. Widespread AD, in particular if this involves the test sites of the forearms.


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • King's College London, Franklin-Wilkins Building.
    150 Stamford Street
    London
    SE19NH

This information has not yet been provided by the study team. You'll have an opportunity to discuss any risks and benefits that may be associated with this study prior to consenting to taking part.

Prof Carsten Flohr
+44 2071887188
Transfoods@kcl.ac.uk


Prof Carsten Flohr
+44 2071887188
Transfoods@kcl.ac.uk


Miss Preeti Khurana
+44 2071887188
Transfoods@kcl.ac.uk



The study is sponsored by King's College London and funded by Biotechnology and Biological Sciences Research Council; Food Standards Agency; Joint Programming Initiative.



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Read full details for Trial ID: ISRCTN12492694
Last updated 03 February 2025

This page is to help you find out about a research study and if you may be able to take part

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