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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Prof Laurence Lovat
+44 (0)20 3108 7859
l.lovat@ucl.ac.uk


Study Location:

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Be Part of Research - Trial Details - Predicting the risk of digestive diseases using a questionnaire approach
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Predicting the risk of digestive diseases using a questionnaire approach

Recruiting

Open to: All Genders

Age: Adult

London Stevenage Harlow London Wigan LONDON

Medical Conditions

Prediction of risk of gastrointestinal diseases

This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


There are numerous lifestyle-altering diseases in the UK for which patients undergo multiple invasive tests before they can be properly diagnosed. These tests are often uncomfortable and inconvenient for patients, in addition to being very costly for the National Health Service (NHS). They typically involve a degree of risk to patients (e.g. bleeding and bowel rupture during endoscopy; or harmful radiation exposure from scanning). Many of these tests also tend to have normal results, since only a small fraction of patients are eventually diagnosed with the disease being sought. This study will focus on using analysis of symptoms and risk factors to predict patients’ risk of developing diseases.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

01 Jan 2020 01 Jan 2030

Publications

2023 Interim results article in https://doi.org/10.1016/j.clinre.2023.102087 Development and validation of a multivariable risk factor questionnaire to detect oesophageal cancer in 2-week wait patients (added 18/07/2023)

You will be asked to sign a consent form to indicate that you are willing to participate in the study. A member of our research team will help you to complete a simple electronic questionnaire about your sociodemographic details (e.g. age, gender, smoking status) and your symptoms (e.g. heartburn, swallowing difficulties, unexplained weight loss, nausea and vomiting). We will also ask you for details of your previous medical history, medication use and family medical history of certain illnesses.
Your participation in the study will take about 30 minutes of your time in total (from reading the consent forms to completing the questionnaire). Your data will subsequently be analysed by our research team to identify the most important factors in predicting the risk of bowel disease as accurate as possible
On some occasions, some patients may be invited to complete further questionnaires in the future, but this, will be entirely your choice, and there will no obligation to continue with the study if you do not wish to do so.


People who may already have had an endoscopy, or are due to have an endoscopy, to check for abnormalities in the gullet (food pipe or oesophagus). Such abnormalities may include inflammation of the gullet wall (e.g. oesophagitis), pre-cancerous conditions (e.g. Barrett’s oesophagus) and even cancer of the gullet (oesophageal cancer).

You can take part if:



You may not be able to take part if:


1. Inability to give informed consent in English, or in the presence of an English translator2. Aged 17 years old and under3. Pregnancy


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • University College London Hospitals NHS Foundation Trust
    250 Euston Road
    London
    NW1 2PG
  • Lister Hospital
    Coreys Mill Lane
    Stevenage
    SG1 4AB
  • Princess Alexandra Hospital
    Hamstel Road
    Harlow
    CM20 1QX
  • Whittington Health NHS Trust
    The Whittington Hospital Magdala Avenue
    London
    N19 5NF
  • Wigan and Leigh Health Services NHS Trust
    Royal Albert Edward Infirmary Wigan Lane
    Wigan
    WN1 2NN
  • NORTH MIDDLESEX UNIVERSITY HOSPITAL NHS TRUST
    NORTH MIDDLESEX HOSPITAL STERLING WAY
    LONDON
    N18 1QX

You will not benefit directly by taking part but may help many other patients in the future by identifying those at high risk of gullet disease via a quick, cheap and simple test using a set of questions. This will help doctors prioritise high-risk patients who need urgent assessment and treatment. It will also save exposing low-risk patients to unnecessary procedures; save significant time and effort for patients, doctors and nurses; and save the NHS and other healthcare organisations significant amounts of money.
The questions you will be asked in the questionnaire are about your health background (e.g. smoking and alcohol consumption) and symptoms that your GP or specialist would already have asked you previously – these questions should therefore not be difficult or upsetting to answer. There is no additional risk involved.
This study aims to compare your questionnaire answers with any diagnosis established by your clinical care team. Therefore, you do not need to worry that the study will reveal any new health-related information about yourself.

Prof Laurence Lovat
+44 (0)20 3108 7859
l.lovat@ucl.ac.uk



The study is sponsored by University College London and funded by Rosetrees Trust; Guts UK.



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Read full details for Trial ID: ISRCTN74930639

Or CPMS 42781

Last updated 18 July 2023

This page is to help you find out about a research study and if you may be able to take part

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