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Contact Information:

Dr Matt Dickinson
matthew.dickinson@nhs.net


Dr Kat Papadopoulou
aikaterini.papadopoulou@nhs.net


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Be Part of Research - Trial Details - The effect of intermittent inflation of an arm tourniquet (remote ischaemic preconditioning) on patient outcomes after surgery for intra-abdominal cancer (RIPCa) - a pilot study
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The effect of intermittent inflation of an arm tourniquet (remote ischaemic preconditioning) on patient outcomes after surgery for intra-abdominal cancer (RIPCa) - a pilot study

Not Recruiting

Open to: All Genders

Age: Adult

Guildford

Medical Conditions

Elective surgery for intra-abdominal cancer

This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


During surgery the body goes through physiological changes that put it under stress and require the presence of adequate blood flow in order to avoid the development of complications. Previous studies have shown that if the blood flow to an arm is briefly reduced (like when a blood pressure cuff is inflated), then the stress to the body is less and the complications are reduced. This technique is called remote ischaemic preconditioning or RIPC. These studies have been done mainly in cardiac surgery. There are only a few studies using RIPC in cancer surgery.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

26 Apr 2019 26 Apr 2020

Publications

2022 Results article in https://pubmed.ncbi.nlm.nih.gov/35407378/ (added 18/07/2022)

Patients will be randomly allocated to either RIPC or standard group. After induction of anaesthesia, the patients in the RIPC group will have a blood pressure cuff around one of their arms inflated 3 times for 5 minutes at a time followed by a 5-minute deflation. The patients in the standard group will not undergo this cuff inflation and deflation. We will also collect blood and urine samples that will be used for measurement of markers of kidney function (urinary biomarkers) and blood flow to the heart (troponin). All patients will be monitored for the development of complications such as infection, bleeding, heart or kidney dysfunction during hospital stay and then via telephone at 1, 3 and 6 months after the operation. The kidney function will also be assessed via a blood test at the routine surgical follow up.


Patients who are scheduled to undergo surgery for intra-abdominal (colorectal, pancreatic, gynaecological) cancer and who are at increased risk of developing complications after their operation will be invited to take part in the study.

You can take part if:



You may not be able to take part if:


1. Patients unable to give consent2. Day surgery3. Emergency surgery4. Total intravenous anaesthesia5. Pregnancy6. Recent (< 1 month) or ongoing acute myocardial infarction7. Unstable or ongoing angina8. Peripheral vascular disease9. History of vascular intervention in the limb to be used for RIPC10. Thromboembolic disease11. Significant coagulopathy or bleeding diathesis12. Sickle cell disease13. Neuromuscular diseases 14. Use of sulfonylureas or nicorandil


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Royal Surrey County Hospital
    Egerton Road
    Guildford
    GU2 7XX

The intervention used in the study may reduce complications after the operation. This may have beneficial effects that extend beyond the immediate period following surgery. The information we get from this study may also help us in the future identify patients at risk of complications early and therefore allow us to take action to prevent these complications occurring.
We do not anticipate any significant side effects of having the cuff applied. The orthopaedic surgeons commonly use a similar cuff for much longer periods. In these cases, side effects are rare and may include pain in the arm, tingling and numbness and rarely damage to the nerves or blood vessels of the arm. However, we are applying the cuff for a continuous period of 5 minutes only.

Dr Kat Papadopoulou
aikaterini.papadopoulou@nhs.net


Dr Matt Dickinson
matthew.dickinson@nhs.net



The study is sponsored by Royal Surrey County Hospital and funded by Inspire Foundation.



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Read full details for Trial ID: ISRCTN11439947

Or CPMS: 38780

Last updated 07 June 2023

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