Ask to take part

Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Prof Waljit S. Dhillo
+44 (0)207 594 3487
imperial.kisspeptin@nhs.net


Dr Ali Abbara
+44 (0)207 594 3487
imperial.kisspeptin@nhs.net


Study Location:

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Be Part of Research - Trial Details - Clinical studies to examine the effect of kisspeptin in delayed puberty

Clinical studies to examine the effect of kisspeptin in delayed puberty

Recruiting

Open to: All Genders

Age: Child

Medical Conditions

Children with delayed puberty


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


Puberty is the time when boys and girls mature into adults, and it usually starts between the ages of 8 and 14. The brain controls puberty, and a small number of children might not start puberty at the same time as most other children. This delay can be caused by a genetic disorder or simply by a normal variation in development. Doctors need to be able to tell the difference between these two groups of children so they can provide the appropriate treatment.

Scientists have found a hormone called 'kisspeptin' that plays an important role in regulating puberty. It works by telling the brain to produce reproductive hormones. Researchers want to study how children with delayed puberty respond to kisspeptin to see if it can help distinguish between those with normal development and those with a genetic disorder. By understanding how kisspeptin affects the body, doctors may be able to create better tests for diagnosing delayed puberty in the future.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

04 Aug 2023 30 Sep 2027

Participants will attend at least two visits in 2 months, at least 1 week apart at The Children's Clinical Research Facility, St Mary's Hospital, London. At visit one GnRH will be administered intravenously and at the other kisspeptin will be administered. Blood samples will be collected through a cannula (tube) not more than every 15 minutes for up to 4 hours [Visit 1] and not more than every 10 minutes for up to 8 hours [Visit 2] to measure reproductive hormone release.


Children with delayed puberty.

You can take part if:



You may not be able to take part if:


1. The child is unable or unwilling to give assent2. Children with untreated anaemia3. Children with a medical condition that could affect the reproductive axis and prevent evaluation of hormonal response to kisspeptin4. Children who are currently in a research study or have participated in research in the last three months


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Imperial College London
    The Children's Clinical Research Facility St Mary’s Hospital Praed Street
    London
    W2 1NY

This information has not yet been provided by the study team. You'll have an opportunity to discuss any risks and benefits that may be associated with this study prior to consenting to taking part.


The study is sponsored by Imperial College London and funded by National Institute for Health and Care Research.




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What will you do next?

Read full details for Trial ID: ISRCTN44496480

Or CPMS 37187

Last updated 18 August 2025

This page is to help you find out about a research study and if you may be able to take part

You can print or share the study information with your GP/healthcare provider or contact the research team directly.