Ask to take part

Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Dr Fergus Caskey
+44 (0)117 414 8150
mdfjc@bristol.ac.uk


Dr Jo Worthington
+44 (0)117 331 4586
Prepare4KC@bristol.ac.uk


More information about this study, what is involved and how to take part can be found on the study website.

Study Location:

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Be Part of Research - Trial Details - Prepare for kidney care

Prepare for kidney care

Medical Conditions

Renal failure


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The kidneys are responsible for filtering out the waste products and excess water in the blood, and converting them into urine. If the kidneys stop working properly, then the body is unable to get rid of the waste products building up in the blood. Eventually, the kidneys are no longer able to support the body’s needs (kidney failure) and so a treatment to replace the work of the failed kidneys is needed. When kidney function drops to 15% of normal, patients experience tiredness, loss of appetite and sickness. At this stage, dialysis or kidney transplantation is considered. Dialysis is a treatment which involves diverting the blood into an external machine so that it can be cleaned, before being returned to the body. This treatment can take place in hospital or at home. There is evidence that some older people with many medical problems (co-morbidities) do just as well with conservative care as dialysis, but more evidence is needed to help patients and their families make the best decision. The aim of this study is to provide clear evidence to help patients and their families reach the best decision for them and influence NHS policy nationally on the best care for people living with kidney disease.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

01 Jul 2017 31 Aug 2024

Publications

2021 Other publications in https://pubmed.ncbi.nlm.nih.gov/32940683/ Background and recruitment progress (added 05/05/2023)2024 Protocol article in https://pubmed.ncbi.nlm.nih.gov/39420412/ (added 29/10/2024)

Participants are randomly allocated to one of two groups. Those in the first group receive conservative care with additional home visits. This involves home visits with a nurse to assess the patient's care needs and their priorities during responsive management. The nurse calls the patient at home regularly to monitor symptoms and check that sufficient help is available. There are regular check-ups with the nurse at home and in-hospital visits. Hospital visits are less frequent than in people preparing for renal dialysis. Those in the second group come to hospital clinic visits regularly as per standard practice. Surgery to prepare for dialysis takes place. Dialysis is started when the doctor, nurse and patient agree it is needed. There are regular visits to hospital for treatment or check-ups. Participants are followed up every four months until the end of data collection or death.


People with kidney failure aged 80+ years and those aged 65+ years with multiple health problems.

You can take part if:



You may not be able to take part if:


1. Unable to consent, e.g. significant cognitive impairment or psychiatric disorder2. Not medically fit for dialysis3. Within 4 weeks of starting dialysis

Added 01/07/2019:4. Patients that have had a previous kidney transplant5. Patients that are 'active' on the kidney transplant waiting list or being worked up for the kidney transplant waiting list


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Southmead Hospital
    Southmead Road Westbury-on-trym
    Bristol
    BS10 5NB
  • Northern General Hospital
    Sheffield
    S5 7AU
  • Royal Preston Hospital
    Sharoe Green Lane Fulwood
    Preston
    PR2 9HT
  • King's College Hospital
    Denmark Hill
    London
    SE5 9RS
  • Queen Alexandra Hospital
    Southwick Hill Road
    Portsmouth
    PO6 3LY
  • Freeman Hospital
    Freeman Road
    Newcastle Upon Tyne
    NE7 7DN
  • Leicester General Hospital
    Gwendolen Road
    Leicester
    LE5 4PW
  • Gloucester Royal Hospital
    Great Western Road
    Gloucester
    GL1 3NN
  • Royal Cornwall Hospital
    Truro
    TR1 3HD
  • Royal Liverpool Hospital
    Prescot Street
    Liverpool
    L7 8XP
  • Queen Elizabeth Hospital
    Queen Elizabeth Medical Centre Edgbaston
    Birmingham
    B15 2TH
  • Craigavon Area Hospital
    Lurgan Rd
    Craigavon
    BT63 5QQ
  • Altnagelvin Area Hospital
    Glenshane Road
    Londonderry
    BT47 6SB
  • Royal Infirmary of Edinburgh
    51 Little France Crescent
    Edinburgh
    EH16 4SA
  • Kent and Canterbury Hospital
    Ethelbert Road
    Canterbury
    CT1 3NG
  • Manchester Royal Infirmary
    Oxford Road
    Manchester
    M13 9WL
  • St Helier Hospital
    Wrythe Lane
    Carshalton
    SM5 1AA
  • Antrim Area Hospital
    45 Bush Rd
    Antrim
    BT41 2RL
  • St Luke's Hospital
    Little Horton Lane
    Bradford
    BD5 0NA
  • Royal Free Hospital
    Renal Unit Pond Street
    London
    NW3 2QG
  • Lister Hospital
    Renal Unit Corerys Mill Lane
    Stevenage
    SG1 4AB
  • Birmingham Heartlands Hospital
    Department of Renal Medicine Bordesley Green East
    Birmingham
    B9 5SS
  • Royal Stoke University Hospital
    Trent Building University Hospitals of North Midlands NHS Trust Newcastle Road
    Stoke-on-Trent
    ST4 6QG
  • The Heath Hospital
    University Hospital of Wales Heath Park
    Cardiff
    CF14 4XW
  • The York Hospital
    Wiggington Road
    York
    YO31 8HE
  • Ipswich Hospital ESNEFT
    Heath Road
    Ipswich
    IP4 5PD
  • Dumfries and Galloway Royal Infirmary
    Cargenbridge
    Dumfries
    DG2 8RX
  • Guy's Hospital
    Great Maze Road
    London
    SE1 9RT
  • Salford Royal Hospital
    544 Eccles New Road, Salford
    Manchester
    M5 5AP
  • Ninewells Hospital & Medical School
    Ninewells Avenue
    Dundee
    DD1 9SY

There are no guaranteed benefits of taking part, however, the treatment given as part of the study may lead to an improvement in symptoms and general health. There are no notable risks involved with participating.

Dr Jo Worthington
+44 (0)117 331 4586
Prepare4KC@bristol.ac.uk


Dr Fergus Caskey
+44 (0)117 414 8150
mdfjc@bristol.ac.uk



More information about this study, what is involved and how to take part can be found on the study website.


The study is sponsored by North Bristol NHS Trust and funded by National Institute for Health Research.





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Read full details for Trial ID: ISRCTN17133653

Or CPMS 32254

Last updated 29 October 2024

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