Ask to take part

Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Miss Rachel Kelly
+44 (0)113 3436912
ctru-laces@leeds.ac.uk


Miss Deena Harji
-
D.Harji@leeds.ac.uk


Study Location:

Skip to Main Content
English | Cymraeg
Be Part of Research - Trial Details - Keyhole versus open colorectal surgery in the emergency setting

Keyhole versus open colorectal surgery in the emergency setting

Medical Conditions

Laparoscopic versus open colorectal surgery


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


Emergency general surgery is one of the most common reasons for admission to hospital. A wide range of problems can lead to emergency admission, and diseases that affect the large bowel (e.g. diverticular disease and cancer) make up a third of diseases that present as an emergency. There are two different types of operation that can be used in surgery: keyhole surgery, which involves several small cuts to allow surgical instruments to access the inside of the body, and open surgery, where a bigger cut is made. Currently, keyhole surgery is used in planned (elective) surgery involving the large bowel, but in the emergency setting surgeons choose open surgery more often. Surgeons think that using keyhole surgery in the emergency setting may result in shorter recovery time, reduced pain and shorter length of hospital stay compared with open surgery, but it is not certain if this is definitely the case as the current evidence is not strong enough to draw any firm conclusions. This study will help determine the effectiveness and cost-effectiveness of keyhole surgery in the emergency setting.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

13 Jun 2022 20 Jun 2024

Participants are randomly allocated to be treated with open surgery or keyhole surgery. Participants will be followed up for 12 months after their operation. The researchers will also collect information about why patients choose to take part in the study or not and ask recruiting staff about the trial and recruitment processes. They will also investigate whether using routine health data could be a reliable way of collecting surgical clinical trial data in future.


Patients aged 18 years and over requiring emergency surgery on the large bowel

You can take part if:



You may not be able to take part if:


1. Acute non-colorectal pathology (for example; adhesional small bowel obstruction, appendicitis, peptic ulcer disease)2. Hand-assisted laparoscopic surgery using a hand port 3. Laparoscopy and peritoneal lavage alone for colorectal pathology4. Insertion of an endoscopic stent followed by laparoscopic resection for obstructing colorectal pathology5. Patients undergoing emergency surgery for complications of elective colorectal operations6. Pregnancy7. Pre-existing cognitive impairment affecting the patient’s capacity to consent


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Nottingham University Hospitals NHS Trust - Queen's Medical Centre Campus
    Nottingham University Hospital Derby Road
    Nottingham
    NG7 2UH
  • Northwick Park Hospital
    Watford Road
    Harrow
    HA1 3UJ
  • St. James's University Hospital
    Beckett Street
    Leeds
    LS9 7TF
  • Glan Clwd Hospital
    Ysbyty Glan Clwydd Bodelwyddan
    Rhyl
    LL18 5UJ
  • Western General Hospital
    Crewe Road South Edinburgh
    Lothian
    EH4 2XU
  • Sunderland Royal Hospital
    Kayll Road
    Sunderland
    SR4 7TP
  • Manchester Royal Infirmary
    Cobbett House Oxford Road
    Manchester
    M13 9WL
  • Darlington Memorial Hospital
    Hollyhurst Road
    Darlington
    DL3 6HX
  • Bradford Royal Infirmary
    Duckworth Lane
    Bradford
    BD9 6RJ
  • Doncaster Royal Infirmary
    Armthorpe Road
    Doncaster
    DN2 5LT
  • Wythenshawe Hospital
    Southmoor Road Wythenshawe
    Manchester
    M23 9LT
  • Scarborough Hospital
    Woodlands Drive
    Scarborough
    YO12 6QL
  • Morriston Hospital
    Heol Maes Eglwys Cwmrhydyceirw
    Swansea
    SA6 6NL
  • James Paget University Hospital
    Lowestoft Road Gorleston
    Great Yarmouth
    NR31 6LA
  • Northumbria Specialist Emergency Care Hospital
    Northumbria Way
    Cramlington
    NE23 6NZ
  • University Hospital of North Tees
    Hardwick Road
    Stockton-on-tees
    TS19 8PE
  • Countess of Chester Hospital
    Countess of Chester Health Park Liverpool Road
    Chester
    CH2 1UL
  • Wrexham Maelor Hospital
    Croesnewydd Road Wrexham Technology Park
    Wrexham
    LL13 7TD
  • Royal Albert Edward Infirmary
    Wigan Lane
    Wigan
    WN1 2NN
  • Arrowe Park Hospital
    Arrowe Park Road
    Wirral
    CH49 5PE
  • York District Hospital
    Wigginton Road
    York
    YO31 8HE
  • The Grange University Hospital
    Caerleon Road
    Cwmbran
    NP44 8YN

Laparoscopic surgery in the emergency setting could lead to reduced pain, shorter recovery time and reduced hospital stays, therefore these are the potential benefits to participants in the laparoscopic group. It is hoped that this study will provide evidence to assist surgeons on the best approach for treating other patients with similar conditions in the future. There are also additional benefits to participants, including close and regular follow-up monitoring and rigorous assessment of outcomes.
All participants will need resectional bowel surgery and currently both types of surgery offered in the study are used in NHS routine practice, so the risks of taking part in the study should not be any different from the risks of being treated outside of the study. If patients choose to take part in the study, they will be asked to give up some of their time to complete questionnaires and attend hospital appointments at certain times, but where possible these will be timed to coincide with normal clinical care.

Miss Rachel Kelly
+44 (0)113 3436912
ctru-laces@leeds.ac.uk


Miss Deena Harji
-
D.Harji@leeds.ac.uk



The study is sponsored by University of Leeds and funded by NIHR Evaluation, Trials and Studies Co-ordinating Centre (NETSCC); Grant Codes: NIHR128815.




We'd like your feedback

Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.


Is this study information helpful?

What will you do next?

Read full details for Trial ID: ISRCTN38815804

Or CPMS 50862

Last updated 07 August 2024

This page is to help you find out about a research study and if you may be able to take part

You can print or share the study information with your GP/healthcare provider or contact the research team directly.