Ask to take part

Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Prof John Geddes


Study Location:

Find another location


Questions to ask
Skip to Main Content
Keep up to date

Sign up for news and information about taking part and shaping research.

Back

OCTUMI-4: Evaluation of Mirtazapine and Folic Acid for Schizophrenia

Not Recruiting

Open to: All Genders

Age: Adult

Oxford

Medical Conditions

Schizophrenia

This information is provided directly by researchers and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information.


Not provided at time of registration

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

01 Apr 2010

31 Dec 2012

Interventional

Intervention Type : Drug
Intervention Description : Participants are randomly allocated to mirtazapine or placebo and separately to folic acid or placebo 1. Mirtazapine or placebo 2. Folic acid or placebo Both as add-on therapies to ongoing antipsychotic treatment

Both allocated medicines are taken orally for 12 weeks with a 2-week tapering period for mirtazapine on completion of the trial. The dose of mirtazapine is 30mg and of folic acid 400 - 500microg. (Participants for whom random allocation of folic acid/placebo is not appropriate can take part in the trial and be randomly allocated to lamotrigine or placebo only.)


You can take part if:



1. Diagnosis of DSM-IV schizophrenia 2. Active psychotic symptoms - i.e. hallucinations, delusions, thought disorder3. Inpatient or outpatient4. Aged 18 to 70 years. 5. Able and willing to consent to participate 6. Minimum score on PANSS 607. Drug treatment stable8. Currently taking effective dose of antipsychotic 9. Adjunctive mirtazapine appears reasonable and both investigator and patient are uncertain whether it will offer any benefit 10. Clinically appropriate to change or augment treatment. Participants for whom random allocation of folic acid or placebo is not appropriate will be allocated mirtazapine or placebo only.

Ammended 22/09/10:4. 16-70 years




You may not be able to take part if:


1. Not meeting criteria for current manic episode including schizoaffective disorder2. No antidepressant treatment within last two weeks and not considering treatment for depression 3. Not taking clozapine4. No contraindication to investigational medicinal products5. Not pregnant, breast-feeding or planning a pregnancy


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • University of Oxford
    Oxford
    OX3 7JX

Prof John Geddes



The study is sponsored by University of Oxford (UK) and funded by Stanley Medical Research Institute (USA).


We'd like your feedback

Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.


Is this study information helpful?

What will you do next?
Read full details

for Trial ID: ISRCTN32434568

Last updated

This page is to help you find out about a research study and if you may be able to take part

You can print or share the study information with your GP/healthcare provider or contact the research team directly.   

Back to the top