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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Ms Christine Rake
+44 (0)20 7636 8636
christine.rake@lshtm.ac.uk


Prof Clare Gilham
+44 (0)20 7636 8636
clare.gilham@lshtm.ac.uk


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Be Part of Research - Trial Details - Catch-up screen project: A urine test for cervical screening
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Catch-up screen project: A urine test for cervical screening

Recruiting

Open to: Female

Age: Senior

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Medical Conditions

Screening for cervical pre-cancer

This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


Human Papillomavirus (HPV) is known to cause almost all cervical cancers, so testing for HPV is the most effective way to identify women at risk of developing cervical cancer. Since 2019, the NHS Cervical Screening Programme (NHS CSP) has offered primary HPV testing to women aged 25-64 years. Women who have an HPV test before they stop screening are at a very low risk of developing cervical cancer. The “Catch-up Screen” project aims to screen at least 10,000 women aged 60-79 from selected GP practices across the Hull and Manchester areas. The women should have exited the NHS Cervical Screening Programme without a primary HPV test. This includes women who had their last screening invitation before the introduction of primary HPV testing in 2019 and women who did not attend their last test after 2019. Unlike traditional screening, which can sometimes be painful or embarrassing, Catch-up Screen involves women providing a urine sample from the privacy of their home. Urine testing has been shown to be as good as traditional smear tests taken by a nurse for the purpose of HPV testing. It is hoped that urine testing will encourage women who were not screened regularly to become engaged. The aim of this 3-year project is to measure response rates, HPV prevalence and histological outcomes to estimate the likely impact on cervical cancer incidence and mortality of a nationwide catch-up screen programme.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

01 Apr 2023 31 Mar 2026

Women will be sent a pre-invitation letter and information leaflet prior to receiving a urine sampling kit by post, for them to provide a first void urine sample from home. They will also be asked to complete a short feedback form to find out how they found using the urine kit. Samples will be posted back to the laboratory and tested for HPV. HPV-negative women will receive a letter with their test results, explaining that their future risk of cervical cancer is extremely low. They will not need any further tests. HPV-positive women will be offered a hospital outpatient appointment with a gynaecologist. During this appointment, the gynaecologist will take a close look at the cervix (this is called a colposcopy) and offer the woman a smear test to check for abnormal cells. If any abnormal cells are found, they can be removed.


Women aged between 60-79 years old who are no longer being invited for cervical screening as part of the NHS programme

You can take part if:



You may not be able to take part if:


1. Previous total hysterectomy 2. Unable to provide a urine sample 3. Unable to understand the Patient Information Sheet and consent form 4. Any condition that would compromise participant safety or data integrity 5. Those who have opted out of sharing data for research purposes (this includes Type 1 and Type 2/National opt-out)


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

The benefit of taking part is receiving an additional cervical screen which would not usually be offered by the NHS. For most women, who will test negative for HPV, the benefit is the reassurance that they are at very low risk of developing cervical cancer in the future. For those who test HPV positive, the benefit is that cervical cancer can be prevented by identifying and treating abnormal cells. The results will also help the NHS to decide whether a catch-up urine test should be offered to all women in their 60s and 70s.
There are no foreseen disadvantages or risks of taking part. Some people may feel anxious while awaiting results, but most results will be normal. Untreated HPV infections can cause abnormal cells that sometimes if left untreated, progress to cervical cancer. It is therefore important that HPV-positive women attend their hospital appointment because failure to do so puts them at increased risk of future cervical cancer.

Ms Christine Rake
+44 (0)20 7636 8636
christine.rake@lshtm.ac.uk


Prof Clare Gilham
+44 (0)20 7636 8636
clare.gilham@lshtm.ac.uk



The study is sponsored by London School of Hygiene & Tropical Medicine and funded by Yorkshire Cancer Research.



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Read full details for Trial ID: ISRCTN39222060

Or CPMS 54834

Last updated 01 February 2023

This page is to help you find out about a research study and if you may be able to take part

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