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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Prof
John
Duncan
+44 (0)20 3448 8612
j.duncan@ucl.ac.uk
Dr
Debayan
Dasgupta
+44 (0)20 8344 8613
debayan.dasgupta@ucl.ac.uk
Epilepsy
This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.
Sixty million people have epilepsy and a third of them continue to have seizures despite medication, with risks of fatality, brain damage, physical harm and psychosocial disorders. Brain surgery (neurosurgery) can control epilepsy if the responsible part of the brain is removed. We have treated 1,074 individuals with epilepsy surgery since February 1990. In optimal circumstances, 80% have no seizures for 1 year or more after surgery, and 40% never have another seizure. There may, however, be adverse effects. After surgery 30% of individuals develop increased difficulty with memory and language, and 10-20% may lose part of their field of vision.
Over the next 4 years we will implement methods to improve epilepsy surgery, streamline the pathway and so improve access:
1. Systematic analysis of seizure symptoms to better understand the areas of the brain involved in each individual. This information is combined with results of brain imaging and other brain scans and electrical recordings from the scalp and viewed in 3-dimensions.
2. Use computer-assisted analysis of brain scans to define the best locations for recording electrodes in the brain at sites thought to be giving rise to seizures, avoiding blood vessels
3. Analyse the electrical signals recorded from electrodes in the brain, integrating this with analysis of MRI and other brain scans to determine which parts need to be removed to control the epilepsy
4. Plan surgery so that there is the best chance of stopping seizures, and minimized risk of other damage
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
You can take part if:
You may not be able to take part if:
1. Lack of capacity to give informed consent2. Comorbidiites that would make neurosurgical intervention inappropriate (e.g., active neoplasia, cerebrovascular disease, dementia, coagulopathy)
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
Prof
John
Duncan
+44 (0)20 3448 8612
j.duncan@ucl.ac.uk
Dr
Debayan
Dasgupta
+44 (0)20 8344 8613
debayan.dasgupta@ucl.ac.uk
The study is sponsored by University College London and funded by Epilepsy Research UK; Grant Codes: UK P1904; Wellcome Trust; Grant Codes: 218380/Z/19/Z.
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Or CPMS 46471
You can print or share the study information with your GP/healthcare provider or contact the research team directly.
