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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Prof Carlo Palmieri
+44 (0)151 706 3616
c.palmieri@liv.ac.uk


More information about this study, what is involved and how to take part can be found on the study website.

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Be Part of Research - Trial Details - PRIMROSE CSF - Cerebrospinal Fluid Collection in Breast Cancer
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PRIMROSE CSF - Cerebrospinal Fluid Collection in Breast Cancer

Not Recruiting

Open to: All Genders

Age: Adult

Liverpool Sheffield Cambridge Oxford Southampton Liverpool Manchester Leeds London Birmingham Bearsden

Medical Conditions

Breast Cancer

This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The PRIMROSE CSF Study aims to study cerebrospinal fluid (CSF) in patients with breast cancer that has spread to the brain (brain metastasis) or the lining surrounding the brain (leptomeningeal disease).
What is CerebroSpinal Fluid (CSF)?
This is the liquid that surrounds and protects the brain and spinal cord. CSF is constantly produced by our body and small amounts removed during extraction procedures are rapidly replaced.
What is a metastasis?
This is when cancer cells break off from the main tumour (in this case – in the breast), enters the blood stream and spreads to another part of the body such as the brain (so called brain metastasis or the thin lining over the brain (so called leptomeningeal disease).
The PRIMROSE CSF Study aims to improve our understanding of breast cancers that spread to the brain/brain lining by collecting and studying the fluid that circulates around the brain and comparing the sample to other cancer samples and blood samples.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

01 Jun 2021 01 Jun 2024

After we check there is no reason why participants cannot have a sample taken, we will ask for consent to the following:
Collection of CSF sample: This will occur via one of two procedures - lumbar puncture or aspiration from Ommaya Reservoir (device inserted in the head).
Collection of Blood sample: This will occur immediately before the CSF extraction procedure. A 20ml blood sample will be collected immediately before lumbar puncture or Ommaya Reservoir.
Collection of Tissue: This will occur almost immediately after participants consent to the CSF Study. We will organise for the collection of breast cancer material which has been collected and stored or which will be collected, as part of routine clinical care.
Optional CSF sample: Roughly three months after the initial collection of CSF sample, participants may be asked to undergo a further CSF extraction as part of routine care. We would also like to obtain a blood sample for the study, should this happen.


Patients aged 16 years or older, recently diagnosed with breast cancer.

You can take part if:



You may not be able to take part if:


1. Unable to comply with study procedures or give informed consent2. Where the investigator considers it unsafe to undertake a lumbar puncture or perform an aspiration from the Ommaya reservoir3. Where the investigator considers it not in the best interest of the patient to participate


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • The Walton Centre NHS Foundation Trust
    Lower Lane
    Liverpool
    L9 7LJ
  • Northern General Hospital
    Sheffield Teaching Hospitals NHS Foundation Trust Herries Road
    Sheffield
    S5 7AU
  • Addenbrooke's Hospital
    Cambridge University Hospitals NHS Foundation Trust Hills Road
    Cambridge
    CB2 0QQ
  • John Radcliffe Hopsital
    Oxford University Hospitals NHS Foundation Trust Headley Way
    Oxford
    OX3 9DU
  • Southampton General Hospital
    University of Southampton and University Hospital Southampton NHS Foundation Trust Tremona Road
    Southampton
    SO16 6YD
  • Royal Liverpool University Hospital
    Royal Liverpool University Hospitals NHS Trust Prescot Street
    Liverpool
    L7 8XP
  • The Christie Hospital
    The Christie NHS Foundation Trust Wilmslow Road Withington
    Manchester
    M20 4BX
  • St James University Hospital
    Leeds Teaching Hospitals NHS Trust Beckett Street
    Leeds
    LS9 7TF
  • Guy’s Hospital
    Guy’s & St Thomas’ NHS Foundation Trust Great Maze Pond
    London
    SE1 9RT
  • Queen Elizabeth Hospital
    University Hospitals Birmingham NHS Foundation Trust Mindelsohn Way
    Birmingham
    B15 2TH
  • Wolfson Wohl Cancer Research Centre
    Garscube Estate Switchbank Road
    Bearsden
    G61 1QH

Research in brain metastases in breast cancer is rare and limited. If we are able to collect enough samples, we will be able to increase the resources for research. Potential risks and side effects of the procedures include infection (rare), nerve root irritation (rare), backpain(rare) and headache (possibly begins immediately or a few days after procedure and usually lasts less than 1 week). To minimise risk: - lumbar punctures will be performed using appropriate local anaesthesia by clinicians experienced in the procedure. - Where patients are undergoing a neurosurgical procedure, the lumbar puncture will be carried out once patient has been anaesthetised so reducing any side effects. - Patients will be followed up roughly a month post-procedure to understand the side effects if any that occur post procedure.

Prof Carlo Palmieri
+44 (0)151 706 3616
c.palmieri@liv.ac.uk



More information about this study, what is involved and how to take part can be found on the study website.


The study is sponsored by University of Liverpool and funded by North West Cancer Research Fund incorporating Clatterbridge Cancer Research; Grant Codes: AR2019.09.



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Read full details for Trial ID: ISRCTN13865526

Or CPMS 47541

Last updated 06 March 2024

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