Ask to take part

Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Alex Cameron 0118 378 6803
a.cameron@pgr.reading.ac.uk


David T Field +44 1183785004
d.t.field@reading.ac.uk


Study Location:

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Be Part of Research - Trial Details - The Effects of High-dose Vitamin B6 on Depression and Anxiety Symptoms

The Effects of High-dose Vitamin B6 on Depression and Anxiety Symptoms

Recruiting

Open to: ALL

Age: 18.0 - 41.0

Medical Conditions

Neural Inhibition
Anxiety
Depression


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


This clinical trial investigates the effects of Vitamin B6 supplementation on neural inhibition using electroencephalography (EEG), in relation to depression and anxiety symptoms in participants from the general population with a relatively high level of symptoms at baseline. Researchers will compare a placebo group to high-dose Vitamin B6 to test the hypothesis that Vitamin B6 moves the excitation/inhibition balance towards inhibition.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

May 2026 Nov 2026

Publications

"Field DT, Cracknell RO, Eastwood JR, Scarfe P, Williams CM, Zheng Y, Tavassoli T. High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression. Hum Psychopharmacol. 2022 Nov;37(6):e2852. doi: 10.1002/hup.2852. Epub 2022 Jul 19."; "35851507"

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : 100mg PLP in the form of a tablet, taken once a day for 1 week

Intervention Arm Group : Pyridoxal-5'-Phosphate supplement;

Intervention Type : DRUG
Intervention Description : Placebo supplement in the form of a capsule.

Intervention Arm Group : Microcrystalline Cellulose Placebo;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Harry Pitt Building
    Reading
    England
    RG6 6ES


The study is sponsored by University of Reading and is in collaboration with eBeauty Ltd Innopure, Regus House, Cardiff Gate Business Park, Malthouse Avenue, Cardiff, CF23 8RU.




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Read full details for Trial ID: NCT07469462
Last updated 27 April 2026

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