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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

AstraZeneca Clinical Study Information Center 1-877-240-9479
information.center@astrazeneca.com


Study Location:

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Be Part of Research - Trial Details - Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2

Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2

Recruiting

Open to: ALL

Age: 18.0 - N/A

Medical Conditions

Gastric Cancer
Gastroesophageal Junction Adenocarcinoma
Esophageal Cancer


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The purpose of this study is to evaluate the efficacy and safety of sonesitatug vedotin in combination with capecitabine with or without rilvegostomig in first-line (1L) Claudin18.2 (CLDN18.2)-positive, human epidermal growth factor receptor 2 (HER2)-negative, gastric, gastroesophageal junction (GEJ), and esophageal adenocarcinoma.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Feb 2026 Aug 2029

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Intravenous

Intervention Arm Group : Arm A;Arm B;Arm D;

Intervention Type : DRUG
Intervention Description : Intravenous

Intervention Arm Group : Arm A;

Intervention Type : DRUG
Intervention Description : Intravenous

Intervention Arm Group : Arm B;Arm C;

Intervention Type : DRUG
Intervention Description : Oral

Intervention Arm Group : Arm A;Arm B;Arm C;Arm D;Arm E;

Intervention Type : DRUG
Intervention Description : Intravenous

Intervention Arm Group : Arm C;Arm E;

Intervention Type : DRUG
Intervention Description : Intravenous

Intervention Arm Group : Arm C;Arm E;

Intervention Type : DRUG
Intervention Description : Intravenous

Intervention Arm Group : Arm E;

Intervention Type : DRUG
Intervention Description : Intravenous

Intervention Arm Group : Arm C;Arm E;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Research Site
    Cambridge
    CB2 0QQ
  • Research Site
    Dundee
    DD1 9SY
  • Research Site
    Manchester
    M20 4BX
  • Research Site
    Oxford
    OX3 7LE
  • Research Site
    London
    EC1A 7BE
  • Research Site
    Leeds
    LS9 7TF

AstraZeneca Clinical Study Information Center 1-877-240-9479
information.center@astrazeneca.com



The study is sponsored by AstraZeneca




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Read full details for Trial ID: NCT07431281
Last updated 23 February 2026

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