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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Sandrine Pouly, PhD +41 58 242 11 11


Christelle Haziza, PhD +41 58 242 11 11
christelle.haziza@pmi.com


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Be Part of Research - Trial Details - Assessment of HPHC Exposure in Smokers Switching to THS/TP18 With Different Device Variants
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Assessment of HPHC Exposure in Smokers Switching to THS/TP18 With Different Device Variants

Recruiting

Open to: ALL

Age: 21.0 - 65.0

Belfast

Medical Conditions

Smoking

This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


This is a randomized, controlled, open-label, 6 parallel arms study to assess reduced exposure of biomarkers of exposure (BoE) of selected HPHC in smokers switching to TP18 (a prototype heated tobacco device) or THS relative to smokers who continue smoking CIG after 5 days of confinement period, followed by 2 days of pharmacokinetic (PK) period of single use of THS/TP18 and CIG, and followed by an ambulatory period.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Feb 2026 Mar 2026

INTERVENTIONAL

Intervention Type : OTHER
Intervention Description : TP18 prototype variant "1" (THS1) and associated tobacco sticks. The Sponsor will supply two types of sticks: regular (tobacco flavor) and non-characterizing menthol flavor. Participants can choose either or both variants.

Intervention Arm Group : THS1;

Intervention Type : OTHER
Intervention Description : TP18 prototype variant "2" (THS2) and associated tobacco sticks. The Sponsor will supply two types of sticks: regular (tobacco flavor) and non-characterizing menthol flavor. Participants can choose either or both variants.

Intervention Arm Group : THS2;

Intervention Type : OTHER
Intervention Description : TP18 prototype variant "3" (THS3) and associated tobacco sticks. The Sponsor will supply two types of sticks: regular (tobacco flavor) and non-characterizing menthol flavor. Participants can choose either or both variants.

Intervention Arm Group : THS3;

Intervention Type : OTHER
Intervention Description : TP18 prototype variant "4" (THS4) and associated tobacco sticks. The Sponsor will supply two types of sticks: regular (tobacco flavor) and non-characterizing menthol flavor. Participants can choose either or both variants.

Intervention Arm Group : THS4;

Intervention Type : OTHER
Intervention Description : THS 3.0 device (reference) and the corresponding tobacco sticks will be provided by the Sponsor. There are two variants of the sticks: regular (tobacco flavor) and non-characterizing menthol flavor. Participants may choose either variant or both.

Intervention Arm Group : THS5;

Intervention Type : OTHER
Intervention Description : Current cigarette smokers will use their usual brand of commercially available CIG.

Intervention Arm Group : CIG;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Celerion
    Belfast
    BT9 6AD

Christelle Haziza, PhD +41 58 242 11 11
christelle.haziza@pmi.com


Sandrine Pouly, PhD +41 58 242 11 11



The study is sponsored by Philip Morris Products S.A.



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Read full details for Trial ID: NCT07443631
Last updated 25 February 2026

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