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Contact Information:

Clinical Trials at Denali Therapeutics Email:
clinical-trials@dnli.com


Study Location:

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Be Part of Research - Trial Details - A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DNL628 in Participants With Early Alzheimer's Disease

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DNL628 in Participants With Early Alzheimer's Disease

Recruiting

Open to: ALL

Age: 18.0 - 75.0

Medical Conditions

Alzheimer Disease, Early Onset


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


This is a Phase 1b, multicenter, randomized, placebo-controlled, double-blind, multiple ascending dose (MAD) study to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of DNL628 in participants with early Alzheimer's disease (AD), defined as mild cognitive impairment, or mild AD with biomarker evidence of amyloid positivity.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Jan 2026 Feb 2027

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Multiple ascending doses

Intervention Arm Group : Experimental Arm;

Intervention Type : DRUG
Intervention Description : Multiple ascending doses

Intervention Arm Group : Placebo Arm;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Clinical Site(s)
    London
    WC1N 3BG

Clinical Trials at Denali Therapeutics Email:
clinical-trials@dnli.com



The study is sponsored by Denali Therapeutics Inc.




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Read full details for Trial ID: NCT07328451
Last updated 20 February 2026

This page is to help you find out about a research study and if you may be able to take part

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