Ask to take part

Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Clinical Trial Information Line 1-877-ALNYLAM
clinicaltrials@alnylam.com


Clinical Trial Information Line 1-877-256-9526
clinicaltrials@alnylam.com


Study Location:

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English | Cymraeg
Be Part of Research - Trial Details - Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease

Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease

Medical Conditions

High Risk Cardiovascular Disease
Hypertension
High Cardiovascular Risk


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The purpose of this study is to evaluate whether zilebesiran versus placebo reduces the risk of cardiovascular (CV) death, nonfatal myocardial infarction (MI), nonfatal stroke, or heart failure (HF) events. This is an event-driven study that will continue until the targeted number of positively adjudicated primary endpoint clinical outcome events (COEs) have been reached.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Sep 2025 Sep 2030

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Zilebesiran will be administered SC

Intervention Arm Group : Zilebesiran 300 mg;

Intervention Type : DRUG
Intervention Description : Placebo will be administered SC

Intervention Arm Group : Placebo;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Clinical Trial Site
    Bellshill
    ML4 3NJ
  • Clinical Trial Site
    Cardiff
    CF15 9SS
  • Clinical Trial Site
    Birmingham
    B15 2SQ
  • Clinical Trial Site
    Birmingham
    B21 9RY
  • Clinical Trial Site
    Bury St Edmunds
    IP33 2QZ
  • Clinical Trial Site
    Cardiff
    CF5 4AD
  • Clinical Trial Site
    Chichester
    PO19 6SE
  • Clinical Trial Site
    Corby
    NN17 2UR
  • Clinical Trial Site
    Glasgow
    G20 7BE
  • Clinical Trial Site
    Ilford
    IG1 4HP
  • Clinical Trial Site
    Leeds
    LS26 9AA
  • Clinical Trial Site
    Liverpool
    L24 7RB
  • Clinical Trial Site
    London
    EC1A 7BE
  • Clinical Trial Site
    Manchester
    M27 8FF
  • Clinical Trial Site
    Penzance
    TR18 3DX
  • Clinical Trial Site
    Poole
    BH16 5PW
  • Clinical Trial Site
    Teeside
    TS19 8PE
  • Clinical Trial Site
    Bristol
    BS2 8HW
  • Clinical Trial Site
    Fowey
    PL23 1DT
  • Clinical Trial Site
    Liskeard
    PL14 3XA
  • Clinical Trial Site
    Newquay
    TR7 1RU
  • Clinical Trial Site
    Plymouth
    PL5 3JB
  • Clinical Trial Site
    Torpoint
    PL11 2TB
  • Clinical Trial Site
    Ashburton
    TQ13 7AP
  • Clinical Trial Site
    Belfast
    BT2 8BG
  • Clinical Trial Site
    Bristol
    BS37 4AX
  • Clinical Trial Site
    Darlington
    DL3 6HX
  • Clinical Trial Site
    Ely
    CB7 5JD
  • Clinical Trial Site
    Heston
    TW5 9ER
  • Clinical Trial Site
    Honiton
    EX14 2NY
  • Clinical Trial Site
    London
    SE6 4LF
  • Clinical Trial Site
    Metropolitan Borough of Wirral
    CH62 6EE
  • Clinical Trial Site
    Middlesbrough
    TS5 6HA
  • Clinical Trial Site
    Milton Keynes
    MK15 0DU
  • Clinical Trial Site
    Northallerton
    DL7 8AW
  • Clinical Trial Site
    Redhill
    RH1 5RH
  • Clinical Trial Site
    Sale
    M33 4BR
  • Clinical Trial Site
    Swansea
    SA2 8QA
  • Clinical Trial Site
    Thetford
    IP24 1JD
  • Clinical Trial Site
    Wolverhampton
    WV9 5HB
  • Clinical Trial Site
    York
    YO24 2RQ

Clinical Trial Information Line 1-877-ALNYLAM
clinicaltrials@alnylam.com


Clinical Trial Information Line 1-877-256-9526
clinicaltrials@alnylam.com



The study is sponsored by Alnylam Pharmaceuticals and is in collaboration with Hoffmann-La Roche.




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Read full details for Trial ID: NCT07181109
Last updated 12 May 2026

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