Ask to take part

Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Dr Mark Hudson
+44(0)191 233 6161
Mark.Hudson@nuth.nhs.uk


Study Location:

Skip to Main Content
English | Cymraeg
Be Part of Research - Trial Details - To understand the impact of rifaximin on the NHS hospital resource use associated with the management of patients with hepatic encephalopathy (HE)

To understand the impact of rifaximin on the NHS hospital resource use associated with the management of patients with hepatic encephalopathy (HE)

Medical Conditions

Hepatic encephalopathy


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


Hepatic encephalopathy (HE) is a nervous system-related mental disorder for which symptoms include level of consciousness, slowing down of thoughts and movements, deterioration of mental status, confusion, and, in severe forms, coma. HE is a common complication of chronic liver cirrhosis caused by abnormal levels of toxins that accumulate in the blood, which are normally excreted in a healthy liver. We are carrying out a clinical study to understand the effect of a drug called rifaximin in treating patients with HE and how rifaximin is used in the management of HE in routine UK clinical practice.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

12 Aug 2014 24 Jun 2015

Publications

2017 Results article in http://fg.bmj.com/content/early/2017/04/07/flgastro-2016-100792 results

Details of all recorded inpatient (including critical care) and A&E episodes will be obtained for all patients, for the full 12-month periods before and after starting on rifaximin, even if rifaximin was discontinued prior to 12 months.


Patients who have been diagnosed with HE and are not taking rifaximin and patients on rifaximin for at least 12 months before the start of the study.

You can take part if:



You may not be able to take part if:


1. Patients receiving rifaximin where subsequent clinical diagnosis excludes hepatic encephalopathy 2. Patients initiated on rifaximin at hospitals not taking part in the study3. Patients for whom hospital records are unavailable


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Royal Free Hospital
    Pond Street
    London
    NW3 2QG
  • Southampton General Hospital
    Tremona Road
    Southampton
    SO16 6YD
  • King's College Hospital
    Denmark Hill
    London
    SE5 9RS
  • Queen Alexandra Hospital
    Southwick Hill Road
    Portsmouth
    PO6 3LY
  • Freeman Hospital
    Freeman Road
    Newcastle upon Tyne
    NE7 7DN
  • Queen's Medical Centre
    Derby Road
    Nottingham
    NG7 2UH
  • Royal Liverpool University Hospital
    Prescot Street
    Liverpool
    L7 8XP
  • Royal Cornwall Hospital
    Penventinnie Lane
    Truro
    TR1 3LQ
  • Addenbrooke's Hospital
    Hills Road
    Cambridge
    CB2 0QQ
  • Southmead Hospital
    Southmead Road
    Bristol
    BS10 5NB
  • Ninewells Hospital
    Ninewells Avenue
    Dundee
    DD2 1UB
  • Royal Victoria Hospital
    Grosvenor Road
    Belfast
    BT12 6BA
  • University Hospital of North Durham
    North Road
    Durham
    DH1 5TW

There is no additional risk to patients from taking part in this study since it only involves a retrospective review by a researcher of their medical records and electronic hospital admissions data.


The study is sponsored by Norgine Ltd (UK) and funded by Norgine Ltd (UK).




We'd like your feedback

Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.


Is this study information helpful?

What will you do next?

Read full details for Trial ID: ISRCTN61977500
Last updated 19 May 2017

This page is to help you find out about a research study and if you may be able to take part

You can print or share the study information with your GP/healthcare provider or contact the research team directly.