We'd like your feedback
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Renal failure
This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.
Acute kidney injury is a potentially life threatening condition which affects 1 in 2 patients in the Intensive Care Unit (ICU). Patients often need dialysis treatment, also called renal replacement therapy. Renal replacement therapy is a treatment that removes toxins and excess fluid from the blood stream. It consists of having a small plastic catheter in a vein in the neck or in the groin through which blood flows through a dialysis machine and is cleansed and excess water is removed. The cleansed blood is then returned to the patient via the same catheter.
One of the major areas of uncertainty for doctors in the ICU is “What is the right intensity of renal replacement therapy for patients with acute kidney injury?” A higher intensity indeed removes more toxins but also removes other substances in the blood, including vitamins, nutrients and important medications. The current usual dose is around 25 ml/kg/hr but clinical practice in the UK is very variable and some patients routinely receive higher doses and some get lower doses. Data from large databases worldwide have suggested that a lower dose is safe and effective and may potentially allow the kidneys to recover faster but confirmation is lacking.
In this study we investigate whether renal replacement therapy at a lower intensity is as effective and safe as currently used doses. Patients who take part will be randomised to receiving renal replacement therapy at usual or lower intensity. There will be no change to any other aspects of treatment.
We aim to recruit 20 patients in the UK. Fully anonymised results will be shared with researchers in Canada who are conducting the same study. The results will inform us whether the study protocol is feasible and how best to design a future larger research study.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Interventional type: Complex Intervention;Management of Care;Other;
You can take part if:
You may not be able to take part if:
At the time of screening, any of the following criteria preclude participation in the trial: • indication for sustained higher dose-intensity CRRT • end-stage kidney disease receiving maintenance dialysis • previous receipt of RRT for AKI during the current hospitalization • inability to comply with the requirements of the study protocol
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
The study is sponsored by GUY'S AND ST THOMAS' NHS FOUNDATION TRUST and funded by Canadian Institutes of Health Research .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 71004
You can print or share the study information with your GP/healthcare provider or contact the research team directly.
