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Be Part of Research - Trial Details - A Clinical Study of Enlicitide in Participants With High Cholesterol (MK-0616-037)

A Clinical Study of Enlicitide in Participants With High Cholesterol (MK-0616-037)

Recruiting

Open to: ALL

Age: 18.0 - 64.0

Medical Conditions

Hyperlipidemia


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


Researchers designed a study medicine called enlicitide to lower low-density lipoprotein cholesterol (LDL-C). In this study, researchers want to learn about giving enlicitide with another medicine called rosuvastatin. Rosuvastatin is a standard (usual) treatment to lower LDL-C.

The goal of this study is to learn if enlicitide given with rosuvastatin works better than placebo on lowering LDL-C in a person's blood. A placebo looks like the study medicine but has no study medicine in it. Using a placebo helps researchers better understand the effects of a study medicine.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Nov 2025 Dec 2026

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Oral Tablet

Intervention Arm Group : Enlicitide;Enlicitide + Rosuvastatin;

Intervention Type : DRUG
Intervention Description : Oral Capsule

Intervention Arm Group : Enlicitide + Rosuvastatin;Rosuvastatin;

Intervention Type : DRUG
Intervention Description : Oral Tablet

Intervention Arm Group : Placebo;Rosuvastatin;

Intervention Type : DRUG
Intervention Description : Oral Capsule

Intervention Arm Group : Enlicitide;Placebo;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Velocity Clinical Research Romford ( Site 0803)
    Bristol
    Bristol, City of
    BS8 2RA
  • Velocity Clinical Research Havering ( Site 0804)
    London
    Havering
    RM1 3PJ
  • Lakeside Surgery ( Site 0802)
    Corby
    Northamptonshire
    NN17 2UR
  • West Walk Surgery ( Site 0801)
    Yate
    Gloucestershire
    BS37 4AX
  • William Harvey Heart Centre ( Site 0800)
    London
    London, City of
    EC1M 6BQ


The study is sponsored by Merck Sharp & Dohme LLC




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Read full details for Trial ID: NCT07216482
Last updated 11 March 2026

This page is to help you find out about a research study and if you may be able to take part

You can print or share the study information with your GP/healthcare provider or contact the research team directly.