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Contact Information:

Dr Dimtrios Koutoukidis
dimitrios.koutoukidis@phc.ox.ac.uk


Mrs Joanna Snowball
joanna.snowball@phc.ox.ac.uk


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Be Part of Research - Trial Details - Could a dietetic led supported weight loss programme help people with cystic fibrosis who have excess weight?
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Could a dietetic led supported weight loss programme help people with cystic fibrosis who have excess weight?

Recruiting

Open to: All Genders

Age: Mixed

London Stoke-on-trent Oxford Southampton

Medical Conditions

Obesity and other hyperalimentation, Metabolic disorders

This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


In the UK, 11,000 people are living with cystic fibrosis (CF), a genetic condition that damages their lungs and digestive system. New medications help them improve their health and quality of life and will likely help them live longer. Before these new medications, people with CF often had low body weight and were advised by specialist dietitians to try and gain weight to a target that was linked to better lung health. Since taking these new medications, 4 in 10 people with CF have now significantly exceeded their target weight, which could harm their future health. People with CF are at higher risk of heart disease and cancers than the general population and these may also be linked to excess weight as they get older.As this is a new issue for people with CF, there has been no research on adapted programmes that could help them lose weight. There are concerns about whether weight loss (a) is safe for people with CF, (b) can fit within their complicated treatment plan and, (c) is possible as it is different to the long-held advice for a high-calorie diet. This study aims to test whether it is practical for people with CF to follow a weight loss programme.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

26 Jan 2026 31 Dec 2026

Patients will receive one-to-one remote support from a specialist dietitian to help them eat less calories and lose weight over 12 weeks and then maintain this weight loss over the next 12 weeks. Individuals will be placed at random in 2 groups: the weight loss programme (20 patients) or routine dietitian care (10 patients). The research team will monitor participants’ lung and overall health to ensure their safety. The research team will find out whether there are enough people who are willing to take part, lose weight and complete their follow up assessments. The research team will speak to participants to understand their experiences of the programme. The research team will discuss how participants felt about the study and gather feedback on anything they found easy or difficult to help make changes to the programme. The research team will also speak to clinicians to find out if they would use the programme in day-to-day practice. The research was designed with a group of 4 people living with CF who all wanted to lose their excess weight. They felt they needed more guidance from their clinical teams to help them lose weight and welcomed this study. They suggested ways to make it easier for people to join the study, stick to the programme, and attend the follow-up assessments. They will continue to be involved in all stages of the research. They will help to interpret the results that will be published in research journals and will work with the CF Trust charity to communicate these to people with CF and health professionals.


Adult patients living with CF who have excess weight.

You can take part if:



You may not be able to take part if:


1. Female participant who is pregnant, lactating or planning pregnancy during the course of the trial2. >= 10% self-reported weight loss in the 6 months before the screening visit 3. Documented decompensated liver disease 4. Documented stage 4-5 kidney disease5. Actively using enteral feeding 6. Currently taking part in other interventional clinical trials, unless agreed in advance by all trial teams (participation in observational studies is allowed)7. Any other significant disease or disorder which, in the opinion of the Investigator, may either put the participants at risk because of participation in the trial, or may influence the result of the trial, or the participant’s ability to participate in the trial


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • King's College Hospital NHS Foundation Trust
    Denmark Hill
    London
    SE5 9RS
  • University Hospitals of North Midlands NHS Trust
    Newcastle Road
    Stoke-on-trent
    ST4 6QG
  • John Radcliffe Hospital
    Headley Way Headington
    Oxford
    OX3 9DU
  • Southampton General Hospital
    Tremona Road
    Southampton
    SO16 6YD

By taking part, participants will help the researchers find out how to help people with CF in the future. Participants in the weight loss programme group may lose weight and this could bring benefits for their health. The standard care group, at the end of the study will be offered a one-off consultation focused on weight loss with a specialist CF dietitian to help them make an action plan if they still want support to reduce your weight. It is not expected that there will side effects from following the intervention but participants will be closely monitored.

Mrs Joanna Snowball
joanna.snowball@phc.ox.ac.uk


Dr Dimtrios Koutoukidis
dimitrios.koutoukidis@phc.ox.ac.uk



The study is sponsored by University of Oxford and funded by National Institute for Health and Care Research.



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Read full details for Trial ID: ISRCTN17298282

Or CPMS: 58557

Last updated 26 March 2026

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