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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Amgen Call Center 866-572-6436
medinfo@amgen.com


Study Location:

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Be Part of Research - Trial Details - Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

Medical Conditions

Heart Failure With Preserved Ejection Fraction
Heart Failure With Mildly Reduced Ejection Fraction
Obesity


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


This trial will examine if maridebart cafraglutide as an adjunct to standard of care will lead to a reduction in heart failure (HF) events such as HF hospitalizations and urgent HF visits, cardiovascular (CV) deaths and improvement in HF symptoms in participants with HF with preserved ejection fraction (HFpEF) and HF with mildly reduced ejection fraction (HFmrEF) who are obese. This is a phase 3, global, multicenter, 2-part trial with a double-blind period and an open-label extension (OLE). The trial is event-driven, and Part 1 will conclude when approximately 850 primary endpoint events have occurred.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Jun 2025 Jun 2028

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Maridebart cafraglutide will be administered SC.

Intervention Arm Group : Maridebart Cafraglutide;

Intervention Type : DRUG
Intervention Description : Placebo will be administered SC.

Intervention Arm Group : Placebo;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Glenfield Hospital
    Leicester
    LE3 9QP
  • Pinderfields Hospital
    Wakefield
    WF1 4DG
  • Royal Bournemouth Hospital
    Bournemouth
    BH7 7DW
  • Southmead Hospital
    Bristol
    BS10 5NB
  • Royal Devon and Exeter Hospital
    Exeter
    EX2 5DW
  • University College London Hospital
    London
    NW1 2BU
  • Glasgow Royal Infirmary
    Glasgow
    G31 2ER
  • St Richards Hospital
    Chichester
    PO19 6SE
  • University Hospital Monklands
    Airdrie
    ML6 0JS
  • University Hospital Crosshouse
    Kilmarnock
    KA2 0BE
  • Wycombe Hospital
    High Wycombe
    HP11 2TT
  • North Tyneside General Hospital
    Ashington
    NE63 9JJ
  • Highlands Clinical Research Facility, Raigmore Hospital
    Inverness
    IV2 3UJ
  • Newcastle NIHR Commercial Research Delivery Centre
    Newcastle upon Tyne
    NE7 7DN
  • Ninewells Hospital and Medicine School
    Dundee
    DD1 9SY

Amgen Call Center 866-572-6436
medinfo@amgen.com



The study is sponsored by Amgen




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Read full details for Trial ID: NCT07037459
Last updated 25 February 2026

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