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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Prof Jacques Pirenne
+32 16 34 87 27
jacques.pirenne@uzleuven.be


Prof Ina Jochmans
+32 16 34 87 27
ina.jochmans@uzleuven.be


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Be Part of Research - Trial Details - Cold oxygenated machine preservation of aged renal donation after cardiovascular death transplants
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Cold oxygenated machine preservation of aged renal donation after cardiovascular death transplants

Not Recruiting

Open to: All Genders

Age: Adult

Leuven

Medical Conditions

Machine perfusion preservation techniques of kidney grafts

This information is provided directly by researchers and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information.


Kidney transplantation is a successful treatment for end-stage renal disease. The standard method of storing and transporting a kidney for transplantation is to perfuse with a cold perfusion solution and store the kidney in an ice box. It has already been shown that machine perfusion preservation improves short term graft function. The aim of this study is to assess whether adding oxygen during the hypothermic machine perfusion (HMP) will reduce damages, decrease ischaemia-reperfusion injury and improve graft function.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

22 Feb 2015 30 Jun 2017

Publications

2020 Results article in https://pubmed.ncbi.nlm.nih.gov/33220737/ results (added 23/11/2020)

Two groups will be compared: a control group (hypothermic machine perfusion with no addition of oxygen) and an intervention group (hypothermic machine perfusion with added oxygen).


Kidneys donated after circulatory death from donors who are 50 years old or older transplanted into 2 different recipients.

You can take part if:



You may not be able to take part if:


Donor:1. An aortic patch too small for a reliable connection2. Too many renal arteries preventing a safe connection

Recipient:1. Multi-organ transplantation2. Planned dual kidney transplantation3. The recipient is unable or unwilling to give informed consent


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • University Hospitals Leuven
    Leuven
    3000

It has been shown that machine perfusion preservation improves short term graft function. The addition of oxygen during hypothermic machine perfusion may be beneficial and may improve graft function.

Prof Ina Jochmans
+32 16 34 87 27
ina.jochmans@uzleuven.be


Prof Jacques Pirenne
+32 16 34 87 27
jacques.pirenne@uzleuven.be



The study is sponsored by University of Oxford (UK) and funded by Seventh Framework Programme (Grant number 305934 – Work Package 4).



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Read full details for Trial ID: ISRCTN32967929
Last updated 23 November 2020

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