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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Clinical Trial Information Line 1-877-ALNYLAM
clinicaltrials@alnylam.com


Clinical Trial Information Line 1-877-256-9526
clinicaltrials@alnylam.com


Study Location:

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Be Part of Research - Trial Details - A Study to Evaluate ALN-5288 in Patients With Alzheimer's Disease

A Study to Evaluate ALN-5288 in Patients With Alzheimer's Disease

Recruiting

Open to: ALL

Age: 40.0 - 80.0

Medical Conditions

Alzheimer's Disease


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The purpose of this study is to:

* Evaluate the safety and tolerability of intrathecal (IT) ALN-5288 in patients with Alzheimer's Disease (AD) * Evaluate the pharmacodynamic (PD) and pharmacokinetic (PK) effects of ALN-5288 after dose administration

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Oct 2025 Mar 2030

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : ALN-5288 will be administered IT.

Intervention Arm Group : ALN-5288;Placebo + ALN-5288;

Intervention Type : DRUG
Intervention Description : Placebo will be administered IT.

Intervention Arm Group : Placebo + ALN-5288;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Clinical Trial Site
    Glasgow
    G51 4TF
  • Clinical Trial Site
    London
    WC1N 3BG

Clinical Trial Information Line 1-877-ALNYLAM
clinicaltrials@alnylam.com


Clinical Trial Information Line 1-877-256-9526
clinicaltrials@alnylam.com



The study is sponsored by Alnylam Pharmaceuticals and is in collaboration with Regeneron Pharmaceuticals.




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Read full details for Trial ID: NCT07214727
Last updated 30 March 2026

This page is to help you find out about a research study and if you may be able to take part

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