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Be Part of Research - Trial Details - A Study of MK-5684 in People With Certain Solid Tumors (MK-5684-015/OMAHA-015)

A Study of MK-5684 in People With Certain Solid Tumors (MK-5684-015/OMAHA-015)

Recruiting

Open to: ALL

Age: 18.0 - N/A

Medical Conditions

Malignant Neoplasm


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


Researchers want to learn if MK-5684 (the study medicine) can treat breast cancer, ovarian cancer, and endometrial cancer. MK-5684, the study medicine, is designed to treat cancer by blocking the body from making steroid hormones.

Researchers will compare MK-5684 to the standard treatments for each cancer type in this study.

The goal of this study is to learn if people who receive MK-5684 live longer without the cancer growing or spreading compared to people who receive a standard treatment.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Aug 2025 Nov 2027

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Tablet for oral administration.

Intervention Arm Group : MK-5684 and Daily Corticosteroids;

Intervention Type : DRUG
Intervention Description : Tablet for oral administration.

Intervention Arm Group : MK-5684 and Daily Corticosteroids;

Intervention Type : DRUG
Intervention Description : Tablet for oral administration.

Intervention Arm Group : MK-5684 and Daily Corticosteroids;

Intervention Type : DRUG
Intervention Description : Hydrocortisone or hydrocortisone/hydrocortisone acetate administered via intramuscular injection as rescue medication.

Intervention Arm Group : MK-5684 and Daily Corticosteroids;

Intervention Type : DRUG
Intervention Description : Administered via intramuscular injection.

Intervention Arm Group : Fulvestrant or Exemestane;

Intervention Type : DRUG
Intervention Description : Tablet for oral administration.

Intervention Arm Group : Fulvestrant or Exemestane;

Intervention Type : DRUG
Intervention Description : Tablet for oral administration.

Intervention Arm Group : Treatment of Physician's Choice;

Intervention Type : DRUG
Intervention Description : Tablet for oral administration.

Intervention Arm Group : Treatment of Physician's Choice;

Intervention Type : DRUG
Intervention Description : Tablet for oral administration.

Intervention Arm Group : Treatment of Physician's Choice;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • The Christie NHS Foundation Trust ( Site 2300)
    Manchester
    M20 4BX
  • University Hospitals Sussex NHS Foundation Trust ( Site 2301)
    East Sussex
    Brighton And Hove
    BN2 1ES
  • The Royal Cornwall Hospital ( Site 2306)
    Truro
    Cornwall
    TR1 3LJ
  • St Bartholomew's Hospital ( Site 2302)
    London
    London, City of
    EC1A 7BE
  • University College Hospital London ( Site 2303)
    London
    London, City of
    NW1 2PG
  • Western General Hospital ( Site 2307)
    Edinburgh
    Midlothian
    EH4 2XU
  • Queen Elizabeth Hospital ( Site 2305)
    Birmingham
    B15 2GW
  • Guy's & St Thomas' NHS Foundation Trust ( Site 2309)
    London
    London, City of
    SE1 9RT


The study is sponsored by Merck Sharp & Dohme LLC





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Read full details for Trial ID: NCT06979596
Last updated 11 May 2026

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