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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Harriet Cannell +447805576688
H.cannell@leedsbeckett.ac.uk


Theocharis Ispogolou T.Ispoglou@leedsbeckett.ac.uk


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Be Part of Research - Trial Details - The Effects of Resistance Training and a Plant-Based Supplement on Perimenopausal Symptoms and Muscle Health.
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The Effects of Resistance Training and a Plant-Based Supplement on Perimenopausal Symptoms and Muscle Health.

Recruiting

Open to: FEMALE

Age: 40.0 - 55.0

Leeds

Medical Conditions

Perimenopause
Menopause

This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The aim of this clinical trial is to determine if resistance training and a newly developed plant-based nutritional supplement can improve the symptoms and musculoskeletal health of perimenopausal women.

The main questions it aims to evaluate are:

1. Can resistance training and the nutritional supplement - both independently and in combination - improve perimenopausal symptoms (e.g. cognition, mood, sleep) and musculoskeletal outcomes (e.g. strength, muscle mass)? 2. What are the acute effects of the nutritional supplement on cognitive function and mood in perimenopausal women, and is this response altered following long-term intake (12 weeks)? 3. What mechanisms may be contributing to the results?

Participants will be split into four groups to allow the researchers to answer the above questions. These are:

1. The nutritional supplement + resistance training 2. The nutritional supplement only 3. The placebo supplement (A look alike capsule that contains no active ingredients) and resistance training 4. The Placebo supplement only.

Participants will:

* Take their allocated supplement daily and perform home-based strength exercise 3 times per week (for exercise groups), for 12 weeks. * Attend the laboratory at the beginning and end of the 12 weeks to assess cognitive function and mood following acute intake of the supplement. * Attend the laboratory every 4 weeks during the 12 week period, for assessment of cognitive function, symptom severity and muscle health. * Provide a blood sample at each visit for assessment of mechanistic pathways.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Mar 2026 Mar 2027

INTERVENTIONAL

Intervention Type : DIETARY_SUPPLEMENT
Intervention Description : Two capsules to give an overall dose of 20 mg of Sarmentosin and 400mg of L-theanine

Intervention Arm Group : Active Supplement Only;Active Supplement and Resistance Training;

Intervention Type : OTHER
Intervention Description : Home-based Resistance training. Exercises will target the lower and upper body and utilise body weight, resistance bands, dumbbells and push-up handles.

Intervention Arm Group : Active Supplement and Resistance Training;Placebo Supplement and Resistance Training;

Intervention Type : DIETARY_SUPPLEMENT
Intervention Description : Capsules matched for taste and appearance, without any active ingredients.

Intervention Arm Group : Placebo Supplement Only;Placebo Supplement and Resistance Training;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Carnegie School of Sport
    Leeds
    North Humberside
    LS2 3AE

Harriet Cannell +447805576688
H.cannell@leedsbeckett.ac.uk


Theocharis Ispogolou T.Ispoglou@leedsbeckett.ac.uk



The study is sponsored by Leeds Beckett University



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Read full details for Trial ID: NCT07135232
Last updated 23 March 2026

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