Ask to take part

Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Anthony Quinn
anthony.quinn@psych.ox.ac.uk


Rachel Upthegrove
rachel.upthegrove@psych.ox.ac.uk


Study Location:

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Be Part of Research - Trial Details - NIHR SMILE BioResource

NIHR SMILE BioResource

Recruiting

Open to: Female / Male

Age: 16 Years - 115 Years

Medical Conditions

Schizophrenia, schizotypal and delusional disorders


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The NIHR Severe Mental Illness Longitudinal Evaluation (SMILE) BioResource is a collaborative project between the NIHR, the University of Oxford, Cardiff University, King’s College London and the University of Birmingham for the Mental Health Translational Research Collaboration (MH-TRC). Severe Mental Illness (SMI) is a term that includes mental health disorders such as psychosis spectrum disorders, schizophrenia, schizoaffective disorders, and severe mood disorders with psychotic symptoms. We do not understand enough about the causes of SMI, whether diagnostic structures are biologically valid, and how best to target new treatments.

Data collection for the SMILE BioResource will take place in the company of a trained research nurse/ clinical researcher. A trained research nurse/ clinical researcher will collect a blood or saliva sample, questionnaire data, responses to a cognitive task, and medical notes from people with SMI to create a resource to support studies investigating biological, social, and environment factors that influence the risk of a person experiencing SMI, and the symptoms they have. Patients with SMI will be invited to consent to:

- donating either a blood sample or a saliva sample at a routine clinical appointment
- completing self-report measures of symptoms and a Health and Lifestyle Questionnaire
- relevant information being gathered from their health records, and other records by the treating team
- contact for recall to future studies based on their data and biological sample

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

13 Nov 2025 31 Jan 2038

Observational

Observational type: Cohort study;



You can take part if:



You may not be able to take part if:


An individual will not be enrolled as a study participant if: • They are unable to provide a blood sample or a saliva sample. • They are unable to complete the study measures (as assessed by a clinician/clinical researcher).


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Northampton General Hospital (acute)
    Cliftonville
    Northampton
    Northamptonshire
    NN1 5BD
  • Goodmayes Hospital - Trust Headquarters
    Tantallon House
    barley Lane
    Ilford
    Essex
    IG3 8XJ
  • Berrywood Hospital
    Berrywood Drive
    Northampton
    Northamptonshire
    NN5 6UD
  • Warneford Hospital
    Warneford Lane
    headington
    Oxford
    Oxfordshire
    OX3 7JX
  • Ysbyty Glan Clwyd
    Glan Clwyd Hospital
    rhuddlan Road
    bodelwyddan
    Rhyl
    Clwyd
    LL18 5UJ
  • Cambridgeshire And Peterborough Mental Health Partnership Tr Hq
    Elizabeth House, Fulbourn Hospital
    cambridge Road
    fulbourn
    Cambridge
    Cambridgeshire
    CB21 5EF
  • Springfield University Hospital
    61 Glenburnie Road
    London
    Greater London
    SW17 7DJ
  • Kingsway Hospital (headquarters)
    Kingsway
    Derby
    Derbyshire
    DE22 3LZ
  • University Hospital
    Queens Medical Centre
    derby Road
    Nottingham
    Nottinghamshire
    NG7 2UH
  • Whiteleaf Centre
    Bierton Road
    Aylesbury
    Buckinghamshire
    HP20 1EG
  • The Uffculme Centre
    52 Queensbridge Road
    moseley
    Birmingham
    West Midlands
    B13 8QY
  • Becklin Centre
    Alma Street
    Leeds
    West Yorkshire
    LS9 7BE
  • WELTON HOUSE
    K9P7R@2.16.840.1.113883.2.1.3.2.4.18.48


The study is sponsored by University of Oxford and funded by NIHR Mental Health Translational Research Collaboration .




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for Trial ID: CPMS 66308

Last updated 27 July 2026

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