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Contact Information:

Study Director 1-877-828-5568
clinicaltrials@beonemed.com


Study Location:

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English | Cymraeg
Be Part of Research - Trial Details - A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)

A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)

Recruiting

Open to: ALL

Age: 18.0 - N/A

Medical Conditions

Chronic Lymphocytic Leukemia
Small Lymphocytic Lymphoma


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The goal of this study is to compare how well sonrotoclax plus obinutuzumab works versus venetoclax plus rituximab in treating adults with relapsed and/or refractory (R/R) chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). The study will also compare how well sonrotoclax plus rituximab works versus venetoclax plus rituxumab in treating adults with R/R CLL/SLL. The safety of these treatments will also be assessed.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Jun 2025 Sep 2029

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Administered orally

Intervention Arm Group : Arm A: Sonrotoclax plus Obinutuzumab;Arm B: Sonrotoclax plus Rituximab;Arm C: Sonrotoclax plus Obinutuzumab (MRD);

Intervention Type : DRUG
Intervention Description : Administered intravenously

Intervention Arm Group : Arm A: Sonrotoclax plus Obinutuzumab;Arm C: Sonrotoclax plus Obinutuzumab (MRD);

Intervention Type : DRUG
Intervention Description : Administered intravenously

Intervention Arm Group : Arm B: Sonrotoclax plus Rituximab;Arm D: Venetoclax plus Rituximab;

Intervention Type : DRUG
Intervention Description : Administered Orally

Intervention Arm Group : Arm D: Venetoclax plus Rituximab;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Kings College Hospital
    London
    SE5 9RS
  • Royal Cornwall Hospitalsnhs Trust
    Truro
    TR1 3LJ
  • University Hospitals Dorset Royal Bournemouth Hospital
    Bournemouth
    BH7 7DW
  • Clatterbridge Cancer Centre
    Metropolitan Borough of Wirral
    CH63 4JY
  • Freeman Hospital
    Newcastle upon Tyne
    NE7 7DN


The study is sponsored by BeOne Medicines and is in collaboration with German CLL Study Group.




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Read full details for Trial ID: NCT06943872
Last updated 17 March 2026

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