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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Bindumalini Rao Baikady, PhD 02034376033
ASPIRE@icr.ac.uk


Aasia Hussain, PhD 02034376301
ASPIRE@icr.ac.uk


Study Location:

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Be Part of Research - Trial Details - Investigating SX-682 in Combination With Apalutamide in Metastatic Castration-resistant Prostate Cancer

Investigating SX-682 in Combination With Apalutamide in Metastatic Castration-resistant Prostate Cancer

Recruiting

Open to: MALE

Age: 18.0 - N/A

Medical Conditions

Metastatic Castrate-Resistant Prostate Cancer (mCRPC)


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


ASpiRE will investigate the effect of the drug SX-682 in combination with Apalutamide in men suffering from metastatic castration-resistant prostate cancer (mCRPC).

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Apr 2025 Oct 2029

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : SX-682 is supplied as 100mg film coated tablets.

Intervention Arm Group : Phase I: Dose Escalation;Phase II: Dose Expansion;

Intervention Type : DRUG
Intervention Description : Apalutamide is supplied as 60mg film coated tablets.

Intervention Arm Group : Phase I: Dose Escalation;Phase II: Dose Expansion;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Belfast Health and Social Care Trust
    Belfast
    BT9 7AB
  • The Royal Marsden NHS Foundation Trust - Drug Development Unit
    Sutton
    SM2 5PT
  • Cambridge University Hospitals NHS Foundation Trust
    Cambridge
    CB2 0QQ

Bindumalini Rao Baikady, PhD 02034376033
ASPIRE@icr.ac.uk


Aasia Hussain, PhD 02034376301
ASPIRE@icr.ac.uk



The study is sponsored by Institute of Cancer Research, United Kingdom and is in collaboration with Prostate Cancer UK; Janssen Pharmaceutica N.V., Belgium; Oncology Institute of Southern Switzerland; Syntrix Biosystems, Inc.; Royal Marsden NHS Foundation Trust; Cambridge University Hospitals NHS Foundation Trust; Belfast Health and Social Care Trust; Institute of Oncology Research (IOR).





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Read full details for Trial ID: NCT07002320
Last updated 03 December 2025

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