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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

First line of the email MUST contain NCT # and Site #.


BMS Clinical Trials Contact Center www.BMSClinicalTrials.com, www.BMSStudyConnect.com 855-907-3286
Clinical.Trials@bms.com


Study Location:

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Be Part of Research - Trial Details - A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)

A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)

Recruiting

Open to: ALL

Age: 55.0 - 90.0

Medical Conditions

Alzheimer Disease
Agitation


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The purpose of this study is to evaluate the long-term efficacy and safety of combined formulation of xanomeline tartrate/trospium chloride in an immediate release (IR) capsule (KarXT) and xanomeline enteric capsules (KarX-EC) in participants with agitation associated with Alzheimer's Disease who completed the parent studies CN012-0023 or CN012-0024.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Dec 2025 Jun 2029

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Specified dose on specified days

Intervention Arm Group : KarXT+KarX-EC;

Intervention Type : DRUG
Intervention Description : Specified dose on specified days

Intervention Arm Group : KarXT+KarX-EC;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • NeuroClin Glasgow
    Motherwell
    ML1 4UF
  • Surrey and Borders Partnership NHS Foundation Trust
    Chertsey
    Surrey
    KT16 9AU
  • Cornwall Partnership NHS Foundation Trust
    Redruth
    TR15 3QE

First line of the email MUST contain NCT # and Site #.


BMS Clinical Trials Contact Center www.BMSClinicalTrials.com, www.BMSStudyConnect.com 855-907-3286
Clinical.Trials@bms.com



The study is sponsored by Bristol-Myers Squibb




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Read full details for Trial ID: NCT06937229
Last updated 01 June 2026

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