Ask to take part

Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Max McLaughlin Callan 020 7679 5531
ctc.caramel@ucl.ac.uk


Marissa Arfan 020 7679 9855
ctc.caramel@ucl.ac.uk


Study Location:

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Be Part of Research - Trial Details - Acalabrutinib and Rituximab in Previously Untreated Mantle Cell Lymphoma

Acalabrutinib and Rituximab in Previously Untreated Mantle Cell Lymphoma

Medical Conditions

Mantle Cell Lymphoma


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


This is a phase II, single-arm, open-label, multicentre study of acalabrutinib and rituximab for elderly or frail patients with previously untreated mantle cell lymphoma.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Nov 2023 Nov 2026

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Patients will receive acalabrutinib 100mg twice daily for up to six 28 day cycles. Patients can receive 100mg once daily for cycle 1, day 1 to day 7, according to the investigator's discretion.

Intervention Arm Group : Acalabrutinib and rituximab;

Intervention Type : DRUG
Intervention Description : Patient will receive rituximab 375 mg/m2 IV on day 1 (+/- 3 days) of each cycle, for a maximum of 6 cycles

Intervention Arm Group : Acalabrutinib and rituximab;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • University College London Hospital
    London
  • Derriford Hospital
    Plymouth
  • Beatson West of Scotland Cancer Centre
    Glasgow
  • Norfolk and Norwich University Hospital
    Norwich
  • The Christie Hospital
    Manchester
  • Royal Stoke Hospital
    Stoke-on-Trent
  • St. Bartholomew's Hospital
    London
  • The Royal Bournemouth Hospital
    Bournemouth
  • Royal Cornwall Hospital
    Cornwall
  • Cancer and Haematology Centre, Churchill Hospital
    Oxford
  • Clatterbridge Cancer Centre
    Metropolitan Borough of Wirral
  • University Hospital of Wales
    Cardiff


The study is sponsored by University College, London and is in collaboration with AstraZeneca.




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Read full details for Trial ID: NCT05004064
Last updated 07 April 2025

This page is to help you find out about a research study and if you may be able to take part

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