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BioNTech clinical trials patient information +49 6131 9084
patients@biontech.de


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Be Part of Research - Trial Details - Safety, Effectiveness, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and Other Investigational Agents for Lung Cancer

Safety, Effectiveness, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and Other Investigational Agents for Lung Cancer

Recruiting

Open to: ALL

Age: 18.0 - N/A

Medical Conditions

Lung Neoplasms
Carcinoma, Non-Small-Cell Lung


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


This is a Phase 2/3, multisite, randomized, open-label study in participants with first-line non-small cell lung cancer (NSCLC).

This study includes two substudies (substudy A and substudy B) that will recruit participants according to histological subtypes due to differences in chemotherapy choice for standard-of-care and type of NSCLC.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Jan 2025 Dec 2029

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Intravenous infusion

Intervention Arm Group : Substudy A Phase 2 - BNT327 Dose 1 + Carboplatin + Pemetrexed;Substudy A Phase 2 - BNT327 Dose 2 + Carboplatin + Pemetrexed;Substudy A Phase 3 - BNT327 + Carboplatin + Pemetrexed;Substudy B Phase 2 - BNT327 Dose 1 + Carboplatin + Paclitaxel;Substudy B Phase 2 - BNT327 Dose 2 + Carboplatin + Paclitaxel;Substudy B Phase 3 - BNT327 + Carboplatin + Paclitaxel;

Intervention Type : DRUG
Intervention Description : Intravenous infusion

Intervention Arm Group : Substudy A Phase 3 - Pembrolizumab + Carboplatin + Pemetrexed;Substudy B Phase 3 - Pembrolizumab + Carboplatin + Paclitaxel;

Intervention Type : DRUG
Intervention Description : Intravenous infusion

Intervention Arm Group : Substudy A Phase 2 - BNT327 Dose 1 + Carboplatin + Pemetrexed;Substudy A Phase 2 - BNT327 Dose 2 + Carboplatin + Pemetrexed;Substudy A Phase 3 - BNT327 + Carboplatin + Pemetrexed;Substudy A Phase 3 - Pembrolizumab + Carboplatin + Pemetrexed;Substudy B Phase 2 - BNT327 Dose 1 + Carboplatin + Paclitaxel;Substudy B Phase 2 - BNT327 Dose 2 + Carboplatin + Paclitaxel;Substudy B Phase 3 - BNT327 + Carboplatin + Paclitaxel;Substudy B Phase 3 - Pembrolizumab + Carboplatin + Paclitaxel;

Intervention Type : DRUG
Intervention Description : Intravenous infusion

Intervention Arm Group : Substudy A Phase 2 - BNT327 Dose 1 + Carboplatin + Pemetrexed;Substudy A Phase 2 - BNT327 Dose 2 + Carboplatin + Pemetrexed;Substudy A Phase 3 - BNT327 + Carboplatin + Pemetrexed;Substudy A Phase 3 - Pembrolizumab + Carboplatin + Pemetrexed;

Intervention Type : DRUG
Intervention Description : Intravenous infusion

Intervention Arm Group : Substudy B Phase 2 - BNT327 Dose 1 + Carboplatin + Paclitaxel;Substudy B Phase 2 - BNT327 Dose 2 + Carboplatin + Paclitaxel;Substudy B Phase 3 - BNT327 + Carboplatin + Paclitaxel;Substudy B Phase 3 - Pembrolizumab + Carboplatin + Paclitaxel;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • New Cross Hospital
    Wolverhampton
    WV10 0QP
  • Velindre NHS Trust, Velindre Cancer Centre
    Cardiff
    CF14 2TL
  • University College Hospital
    London
    NW2 1PG
  • Royal Preston Hospital - Lancashire Teaching Hospitals NHS Foundation Trust
    Preston
    PR2 9HT
  • Hull University Teaching Hospitals NHS Trust
    Cottingham
    HU16 5JQ
  • Cancer And Haematology Centre-The Churchill Hospital-Oxford University Hospitals
    Oxford
    OX3 7LJ

BioNTech clinical trials patient information +49 6131 9084
patients@biontech.de



The study is sponsored by BioNTech SE and is in collaboration with Biotheus Inc..




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Read full details for Trial ID: NCT06712316
Last updated 15 May 2025

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