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Be Part of Research - Trial Details - A Phase 3 Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria (CSU)

A Phase 3 Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria (CSU)

Medical Conditions

Chronic Spontaneous Urticaria


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The purpose of this study is to establish the efficacy, safety and tolerability of barzolvolimab in adult participants with Chronic Spontaneous Urticaria (CSU) inadequately controlled by non-sedating second generation H1-antihistamines in comparison to placebo.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Jul 2024 Oct 2026

INTERVENTIONAL

Intervention Type : BIOLOGICAL
Intervention Description : Subcutaneous Administration

Intervention Arm Group : Placebo then barzolvolimab 150 mg;Placebo then barzolvolimab 300 mg;barzolvolimab 150 mg;barzolvolimab 300 mg;

Intervention Type : BIOLOGICAL
Intervention Description : Matching placebo Subcutaneous Administration

Intervention Arm Group : Placebo then barzolvolimab 150 mg;Placebo then barzolvolimab 300 mg;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Pinderfields Hospital
    Wakefield
    WF1 4DG
  • Southmead Hospital
    Bristol
    BS10 5NB
  • Royal Berkshire Hospital
    Reading
    RG1 5AN
  • Western General Hospital
    Edinburgh
    EH4 2XU
  • Queen Elizabeth University Hospital
    Glasgow
    G51 4TF
  • The Royal London Hospital
    London
    E1 1FR
  • University Hospitals Plymouth NHS Trust
    Plymouth
    PL6 5FP
  • Velocity Clinical Research, North London - PPDS
    North Finchley
    N12 8BU
  • Cambridge University Hospitals, Addenbrooke's Hospital
    Cambridge
    CB2 0QQ
  • Virtual Clinical Trials Centre, The Stables
    Oxford
    OX44 9PU
  • Velocity Clinical Research High Wycombe
    High Wycombe
    HP11 2QW
  • Velocity Clinical Research - Romford
    Romford
    RM1 3PJ
  • St James's University Hospital
    Leeds
    LS9 7TF


The study is sponsored by Celldex Therapeutics




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Read full details for Trial ID: NCT06455202
Last updated 24 March 2026

This page is to help you find out about a research study and if you may be able to take part

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