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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Daiichi Sankyo Contact for Clinical Trial Information 9089926400
CTRinfo@dsi.com


Study Location:

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Be Part of Research - Trial Details - A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

Recruiting

Open to: ALL

Age: 18.0 - N/A

Medical Conditions

Carcinoma
Prostatic Neoplasms
Melanoma
Stomach Neoplasms
Head and Neck Neoplasms
Uterine Cervical Neoplasms
Urinary Bladder Neoplasms
Endometrial Neoplasms
Ovarian Neoplasms
Carcinoma, Ovarian Epithelial
Pancreatic Neoplasms


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


This is a proof-of-concept study designed to investigate HER3-DXd monotherapy in locally advanced or metastatic solid tumors. The study is enrolling cohorts of participants with melanoma \[cutaneous/acral\], squamous cell carcinomas of the head and neck (SCCHN), and HER2-negative gastric cancerovarian carcinoma, cervical cancer, endometrial cancer, bladder cancer, esophageal carcinoma, pancreatic carcinoma, and prostate cancer.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Feb 2024 Jun 2025

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Intravenous infusion 5.6 mg/kg administered Q3W on Day 1 of each 21-day cycle

Intervention Arm Group : HER3-DXd Monotherapy;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • University Hospital Coventry
    Coventry
    CV2 2DX
  • Royal Free Hospital
    London
    NW3 2QG
  • Barts Hospital
    London
    EC1A 7BE
  • Nottingham City Hospital Campus
    Nottingham
    NG5 1PB

Daiichi Sankyo Contact for Clinical Trial Information 9089926400
CTRinfo@dsi.com



The study is sponsored by Daiichi Sankyo and is in collaboration with Merck Sharp & Dohme LLC.




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Read full details for Trial ID: NCT06172478
Last updated 12 May 2025

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