Ask to take part

Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Clinical Trial Disclosure & Transparency 215-832-3750
ClinicalTrialDisclosure@JazzPharma.com


Study Location:

Skip to Main Content
English | Cymraeg
Be Part of Research - Trial Details - Efficacy and Safety of Zanidatamab With Standard-of-care Therapy Against Standard-of-care Therapy for Advanced HER2-positive Biliary Tract Cancer

Efficacy and Safety of Zanidatamab With Standard-of-care Therapy Against Standard-of-care Therapy for Advanced HER2-positive Biliary Tract Cancer

Recruiting

Open to: ALL

Age: 18.0 - N/A

Medical Conditions

Biliary Tract Neoplasms


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The purpose of this study is to evaluate the efficacy and safety of Zanidatamab plus CisGem (Cisplatin and Gemcitabine) with or without the addition of a programmed death protein 1/ligand-1 (PD-1/L1) inhibitor (physician's choice of either Durvalumab or Pembrolizumab, where approved under local regulations) as first line of treatment for participants with human epidermal growth factor receptor 2 (HER2)-positive biliary tract cancer.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Jul 2024 Dec 2028

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Administered intravenously (IV)

Intervention Arm Group : Zanidatamab with Standard-of-care Therapy Arm;

Intervention Type : DRUG
Intervention Description : Administered intravenously (IV)

Intervention Arm Group : Standard-of-care Therapy Arm;Zanidatamab with Standard-of-care Therapy Arm;

Intervention Type : DRUG
Intervention Description : Administered intravenously (IV)

Intervention Arm Group : Standard-of-care Therapy Arm;Zanidatamab with Standard-of-care Therapy Arm;

Intervention Type : DRUG
Intervention Description : Administered intravenously (IV)

Intervention Arm Group : Standard-of-care Therapy Arm;Zanidatamab with Standard-of-care Therapy Arm;

Intervention Type : DRUG
Intervention Description : Administered intravenously (IV)

Intervention Arm Group : Standard-of-care Therapy Arm;Zanidatamab with Standard-of-care Therapy Arm;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • The Christie NHS Foundation Trust
    Manchester
    England
    M20 4BX
  • Western General Hospital, Edinburgh Cancer Centre
    Edinburgh
    Scotland
    EH4 2XU
  • Mount Vernon Cancer Centre
    London
    England
    HA 6 2RN
  • NHS Foundation Trust Royal Marsden Hospital
    London
    England
    SW3 6JJ
  • Royal Marsden Hospital NHS Foundation Trust
    Surrey
    England
    SM2 5PT

Clinical Trial Disclosure & Transparency 215-832-3750
ClinicalTrialDisclosure@JazzPharma.com



The study is sponsored by Jazz Pharmaceuticals




We'd like your feedback

Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.


Is this study information helpful?

What will you do next?

Read full details for Trial ID: NCT06282575
Last updated 20 June 2025

This page is to help you find out about a research study and if you may be able to take part

You can print or share the study information with your GP/healthcare provider or contact the research team directly.