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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Dr Steve Walker
-
steven.walker@bristol.ac.uk


Ms Jenny Symonds
-
Jenny.Symonds@nbt.nhs.uk


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Be Part of Research - Trial Details - Advanced CT examination of collapsed lungs: looking for the leak point
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Advanced CT examination of collapsed lungs: looking for the leak point

Recruiting

Open to: All Genders

Age: Adult

Bristol

Medical Conditions

Pneumothorax

This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


This study is designed to assess whether we can use a CT scan to identify the site of an air leak in patients with a collapsed lung (pneumothorax) and whether having a tube in to remove the air (an intercostal chest drain) makes the leak of air from the lung worse.
Information from this study may serve as a basis for larger research studies in the future, which could change the way that we manage patients with a collapsed lung; being able to identify where the air is leaking from opens the door for future research into providing targeted treatments to seal the leak, and knowing whether tube drainage is worsening or prolonging the leak of air may reassure us that we can take patients’ tubes out earlier without risking the lung collapsing again.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

30 Nov 2024 01 Jan 2026

A member of the study team will discuss the study with you and assess whether you are suitable. If you are happy to take part, a CT will be requested for you as soon as is practical. In the radiological department, you will be asked to lie down in the CT scanner. A member of the study team will close of your chest drain and administer sterile water solution through your drain. You will be asked to make a long loud noise. The will be four phases of CT scans. There is no follow-up requirements with the study.


Potential participants will be identified from patients presenting with a traumatic, iatrogenic or spontaneous pneumothorax to North Bristol NHS Trust by a clinician working within the trust.

You can take part if:



You may not be able to take part if:


1. Unable to lie flat2. Unable to tolerate clamped ICD3. Aged less than 50 years of age4. Pregnant or breastfeeding patient5. Inability to consent or comply with trial requirements.


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Southmead Hospital
    Southmead Road Westbury-on-trym
    Bristol
    BS10 5NB

Benefits:
Your participation in this study will help improve our understanding of air leak in patients with pneumothorax and evaluate how good this CT scanning technique is at demonstrating an air leak. With this information, we will be able to run larger studies, with the results of which we may be able to offer more targeted therapies to treat air leak and resolve a patient’s pneumothorax more quickly. This could benefit patients in your position in the future.
Risks:
During the study, we will administer 500ml of 0.9% sodium chloride (saline) solution into the chest drain. Saline is commonly used in patients with chest drains; we will often flush a chest drain several times a day to ensure that it doesn’t become blocked or use larger volumes of saline to break down pockets of fluid in patients with infection in their pleural space. The saline itself is very safe but sometimes can be a little uncomfortable as it is administered and can sometimes leak out from around the drain as well as through it. There is a very small risk that we can introduce infection into the space when we access the drain to administer the saline, but we wash our hands, wear sterile gloves and clean the tap attached to the drain thoroughly to reduce that risk.
On occasion, air can accumulate again in the pleural space when the drain is closed off, if the air leak continues. A member of the study team will be present during your CT scan and will be monitoring you closely. If you feel more breathless or develop worsening chest pain during the CT scan, let the radiographer know and we will open the drain again. This will allow any air that has accumulated to drain out and resolve your symptoms quickly.
If you take part in this study, you will have a multi-phase CT scan of the chest. This will be extra to that which you would have if you did not take part in the trial. This procedure uses ionising radiation to form images of your body and provide your doctor with other clinical information. Ionising radiation may cause cancer many years or decades after the exposure. We are all at risk of developing cancer during our lifetime. 50% of the population is likely to develop one of the many forms of cancer at some stage during our lifetime. Taking part in this study will increase the chances of this happening to you to about 50.11 % (0.11% increase over natural incidence).

Dr Steve Walker
-
steven.walker@bristol.ac.uk


Ms Jenny Symonds
-
Jenny.Symonds@nbt.nhs.uk



The study is sponsored by North Bristol NHS Trust and funded by Academy of Medical Sciences.



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What will you do next?
Read full details for Trial ID: ISRCTN21828354

Or CPMS 61757

Last updated 30 December 2024

This page is to help you find out about a research study and if you may be able to take part

You can print or share the study information with your GP/healthcare provider or contact the research team directly.   

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