Ask to take part

Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Clinical Trial Disclosure & Transparency 215-832-3750
ClinicalTrialDisclosure@JazzPharma.com


Study Location:

Skip to Main Content
English | Cymraeg
Be Part of Research - Trial Details - A Study Comparing the Efficacy and Safety of Zanidatamab to Trastuzumab, Each in Combination With Physician's Choice Chemotherapy, for the Treatment of Participants With Metastatic HER2-positive Breast Cancer

A Study Comparing the Efficacy and Safety of Zanidatamab to Trastuzumab, Each in Combination With Physician's Choice Chemotherapy, for the Treatment of Participants With Metastatic HER2-positive Breast Cancer

Recruiting

Open to: ALL

Age: 18.0 - N/A

Medical Conditions

Breast Neoplasms


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The efficacy and safety of zanidatamab in combination with physician's choice of chemotherapy compared with trastuzumab in combination with physician's choice of chemotherapy will be evaluated for the treatment of participants with metastatic HER2-positive breast cancer who have progressed on, or are intolerant to, previous T-DXd treatment.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Aug 2024 Sep 2028

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Administered by intravenous infusion

Intervention Arm Group : Zanidatamab plus physician's choice of chemotherapy;

Intervention Type : DRUG
Intervention Description : Administered by intravenous infusion

Intervention Arm Group : Trastuzumab plus physician's choice of chemotherapy;

Intervention Type : DRUG
Intervention Description : Administered by intravenous infusion

Intervention Arm Group : Trastuzumab plus physician's choice of chemotherapy;Zanidatamab plus physician's choice of chemotherapy;

Intervention Type : DRUG
Intervention Description : Administered by intravenous infusion

Intervention Arm Group : Trastuzumab plus physician's choice of chemotherapy;Zanidatamab plus physician's choice of chemotherapy;

Intervention Type : DRUG
Intervention Description : Administered by intravenous infusion

Intervention Arm Group : Trastuzumab plus physician's choice of chemotherapy;Zanidatamab plus physician's choice of chemotherapy;

Intervention Type : DRUG
Intervention Description : Given orally

Intervention Arm Group : Trastuzumab plus physician's choice of chemotherapy;Zanidatamab plus physician's choice of chemotherapy;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • New Cross Hospital
    Wolverhampton
    WV10 0QP
  • Churchill Hospital
    Oxford
    OX3 7LJ
  • Guy's Hospital
    London
    SE1 9RT
  • Royal United Hospital
    Bath
    BA1 3NG
  • Charring Cross Hospital
    London
    W6 8RF
  • The Christie - PPDS
    Manchester
    M20 4BX
  • Beatson West Of Scotland Cancer Centre
    Glasgow
    G12 0YN

Clinical Trial Disclosure & Transparency 215-832-3750
ClinicalTrialDisclosure@JazzPharma.com



The study is sponsored by Jazz Pharmaceuticals





We'd like your feedback

Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.


Is this study information helpful?

What will you do next?

Read full details for Trial ID: NCT06435429
Last updated 20 June 2025

This page is to help you find out about a research study and if you may be able to take part

You can print or share the study information with your GP/healthcare provider or contact the research team directly.