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Be Part of Research - Trial Details - A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)

A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)

Medical Conditions

Carcinoma, Non-Small-Cell Lung


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The goal of this study is to learn if people who receive intismeran autogene and pembrolizumab after surgery are cancer-free longer than people who receive placebo and pembrolizumab. Researchers want to know if giving intismeran autogene and pembrolizumab after surgery can help prevent the cancer from coming back in people with non-small cell lung cancer (NSCLC) whose tumors did not respond completely to treatment before surgery (neoadjuvant treatment).

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Oct 2024 May 2033

INTERVENTIONAL

Intervention Type : BIOLOGICAL
Intervention Description : IV Infusion

Intervention Arm Group : Pembrolizumab + Intismeran autogene;Pembrolizumab + Placebo;

Intervention Type : DRUG
Intervention Description : IV infusion

Intervention Arm Group : Pembrolizumab + Intismeran autogene;Pembrolizumab + Placebo;

Intervention Type : DRUG
Intervention Description : IV infusion

Intervention Arm Group : Pembrolizumab + Intismeran autogene;Pembrolizumab + Placebo;

Intervention Type : DRUG
Intervention Description : IV infusion

Intervention Arm Group : Pembrolizumab + Intismeran autogene;Pembrolizumab + Placebo;

Intervention Type : DRUG
Intervention Description : IV infusion

Intervention Arm Group : Pembrolizumab + Intismeran autogene;Pembrolizumab + Placebo;

Intervention Type : DRUG
Intervention Description : IV infusion

Intervention Arm Group : Pembrolizumab + Intismeran autogene;Pembrolizumab + Placebo;

Intervention Type : BIOLOGICAL
Intervention Description : IM injection

Intervention Arm Group : Pembrolizumab + Intismeran autogene;

Intervention Type : OTHER
Intervention Description : IM injection

Intervention Arm Group : Pembrolizumab + Placebo;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • St Bartholomews Hospital ( Site 2052)
    London
    London, City of
    EC1A 7BE
  • Bristol Haematology and Oncology Centre ( Site 2072)
    Bristol
    Bristol, City of
    BS2 8ED
  • St James University Hospital ( Site 2055)
    Leeds
    LS9 7TF
  • Nottingham City Hospital ( Site 2058)
    Nottingham
    Nottinghamshire
    NG5 1PB
  • Guys Hospital ( Site 2057)
    London
    London, City of
    SE1 3SS
  • Royal Free Hospital ( Site 2074)
    London
    London, City of
    NW3 2QG
  • The Clatterbridge Cancer Centre ( Site 2069)
    Metropolitan Borough of Wirral
    CH63 4JY
  • ROYAL MARSDEN HOSPITAL (CHELSEA)-Lung Unit ( Site 2075)
    London
    Kensington and Chelsea
    SW3 6JJ
  • Royal Marsden Hospital (Sutton) ( Site 2076)
    London
    London, City of
    SW3 6JJ
  • Leicester Royal Infirmary ( Site 2051)
    Leicester
    LE1 5WW
  • Queen Alexandra Hospital ( Site 2059)
    Portsmouth
    PO6 3LY
  • The Christie NHS Foundation Trust ( Site 2066)
    Manchester
    M20 4BX


The study is sponsored by Merck Sharp & Dohme LLC and is in collaboration with ModernaTX, Inc..




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Read full details for Trial ID: NCT06623422
Last updated 20 February 2026

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