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Contact Information:

Prof Andrew Metcalfe
+44 (0)24 76575288
a.metcalfe@warwick.ac.uk


Dr Fatema Dhaif
+44 2476963587
fatema.dhaif@warwick.ac.uk


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Be Part of Research - Trial Details - What are the treatments and outcomes of people with obesity and severe knee osteoarthritis?
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What are the treatments and outcomes of people with obesity and severe knee osteoarthritis?

Recruiting

Open to: All Genders

Age: Adult

Middlesbrough Coventry Birmingham Luton Harlow Milton Keynes North Shields Wigan

Medical Conditions

Knee osteoarthritis

This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


In the UK, nearly 18.5 million people live with obesity, making them almost five times more likely to develop knee arthritis compared to those with normal weight. Severe knee arthritis can be treated with a knee replacement, but many areas in the UK have rules that prevent obese people from having this surgery. This study aims to understand how best to help people with obesity and severe knee arthritis, whether they can have surgery or not. It will look at current treatments, how well they work for knee pain, and the relationship between weight, body image, and knee pain.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

01 Dec 2024 31 Dec 2025

1. Interview study: Participants will answer questions about their feelings regarding the care they receive for knee arthritis and their weight. The researcher will identify common themes from these interviews to understand what people think about NHS treatments for arthritis and obesity.
2. Cohort study: 210 people with obesity will be asked to participate from three hospitals. They will answer questions about knee pain, disability, and body image at their appointment or at home. They will be contacted again 6 and 12 months later to update on their weight, treatments received, any surgeries, knee pain, and quality of life. This will help identify which factors most strongly impact knee pain.
3. Measurement of key patterns: 190 more people of any weight with severe arthritis will fill in surveys at one time point. These surveys will measure knee pain, disability, and body image. The answers will be analyzed to find patterns and connections between knee pain, body image, and care experiences.


Adults with severe knee arthritis of any weight who have good enough English language skills to respond to questionnaires can participate.

You can take part if:



You may not be able to take part if:


1. Presence of inflammatory arthritis2. History of intra-articular fracture causing post-traumatic arthritis3. Previous surgery on the ipsilateral knee only an exclusion criteria if implants were inserted4. Unable or unwilling to comply with follow up procedure5. Unable to provide informed consent (e.g does not have capacity to consent)6. Insufficient English language skills to understand study materials and respond to questionnaires


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • South Tees Hospitals NHS Foundation Trust
    James Cook University Hospital Marton Road
    Middlesbrough
    TS4 3BW
  • University Hospitals Coventry and Warwickshire NHS Trust
    Walsgrave General Hospital Clifford Bridge Road
    Coventry
    CV2 2DX
  • University Hospitals Birmingham NHS Foundation Trust
    Queen Elizabeth Hospital Mindelsohn Way Edgbaston
    Birmingham
    B15 2GW
  • Luton and Dunstable University Hospital
    Lewsey Road
    Luton
    LU4 0DZ
  • Princess Alexandra Hospital
    Hamstel Road
    Harlow
    CM20 1QX
  • Milton Keynes University Hospital
    Standing Way Eaglestone
    Milton Keynes
    MK6 5LD
  • Northumbria Healthcare NHS Foundation Trust
    North Tyneside General Hospital Rake Lane
    North Shields
    NE29 8NH
  • Wrightington, Wigan and Leigh Teaching Hospitals NHS Foundation Trust
    The Elms Royal Albert Edward Infirmary Wigan Lane
    Wigan
    WN1 2NN

There are no specific benefits to taking part, but participants will help improve knowledge about the links between psychosocial factors and knee pain, aiding future patient care and research. There are no additional physical risks as the study does not change or influence treatment pathways.

Dr Fatema Dhaif
+44 2476963587
fatema.dhaif@warwick.ac.uk


Prof Andrew Metcalfe
+44 (0)24 76575288
a.metcalfe@warwick.ac.uk



The study is sponsored by University of Warwick and funded by National Institute for Health and Care Research.




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Read full details for Trial ID: ISRCTN42984928

Or CPMS 64836

Last updated 10 July 2025

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