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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Dr Fatema Dhaif
+44 2476963587
fatema.dhaif@warwick.ac.uk


Prof Andrew Metcalfe
+44 (0)24 76575288
a.metcalfe@warwick.ac.uk


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Be Part of Research - Trial Details - What are the treatments and outcomes of people with obesity and severe knee osteoarthritis?
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What are the treatments and outcomes of people with obesity and severe knee osteoarthritis?

Recruiting

Open to: All Genders

Age: Adult

Coventry Birmingham Nottingham Camberley North Shields

Medical Conditions

Knee osteoarthritis

This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


In the UK, nearly 18.5 million people live with obesity, making them almost five times more likely to develop knee arthritis compared to those with normal weight. Severe knee arthritis can be treated with a knee replacement, but many areas in the UK have rules that prevent obese people from having this surgery. This study aims to understand how best to help people with obesity and severe knee arthritis, whether they can have surgery or not. It will look at current treatments, how well they work for knee pain, and the relationship between weight, body image, and knee pain.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

01 Dec 2024 01 Dec 2025

1. Interview study: Participants will answer questions about their feelings regarding the care they receive for knee arthritis and their weight. The researcher will identify common themes from these interviews to understand what people think about NHS treatments for arthritis and obesity.
2. Cohort study: 210 people with obesity will be asked to participate from three hospitals. They will answer questions about knee pain, disability, and body image at their appointment or at home. They will be contacted again 6 and 12 months later to update on their weight, treatments received, any surgeries, knee pain, and quality of life. This will help identify which factors most strongly impact knee pain.
3. Measurement of key patterns: 190 more people of any weight with severe arthritis will fill in surveys at one time point. These surveys will measure knee pain, disability, and body image. The answers will be analyzed to find patterns and connections between knee pain, body image, and care experiences.


Adults with severe knee arthritis of any weight who have good enough English language skills to respond to questionnaires can participate.

You can take part if:



You may not be able to take part if:


1. Presence of inflammatory arthritis2. History of intra-articular fracture causing post-traumatic arthritis3. Previous surgery on the ipsilateral knee only an exclusion criteria if implants were inserted4. Unable or unwilling to comply with follow up procedure5. Unable to provide informed consent (e.g does not have capacity to consent)6. Insufficient English language skills to understand study materials and respond to questionnaires


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • University Hospitals Coventry and Warwickshire NHS Trust
    Walsgrave General Hospital Clifford Bridge Road
    Coventry
    CV2 2DX
  • University Hospitals Birmingham NHS Foundation Trust
    Queen Elizabeth Hospital Mindelsohn Way Edgbaston
    Birmingham
    B15 2GW
  • Nottingham University Hospitals NHS Trust - Queen's Medical Centre Campus
    Nottingham University Hospital Derby Road
    Nottingham
    NG7 2UH
  • Frimley Health NHS Foundation Trust
    Portsmouth Road Frimley
    Camberley
    GU16 7UJ
  • Northumbria Healthcare NHS Foundation Trust
    North Tyneside General Hospital Rake Lane
    North Shields
    NE29 8NH

There are no specific benefits to taking part, but participants will help improve knowledge about the links between psychosocial factors and knee pain, aiding future patient care and research. There are no additional physical risks as the study does not change or influence treatment pathways.

Prof Andrew Metcalfe
+44 (0)24 76575288
a.metcalfe@warwick.ac.uk


Dr Fatema Dhaif
+44 2476963587
fatema.dhaif@warwick.ac.uk



The study is sponsored by University of Warwick and funded by National Institute for Health and Care Research.




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Read full details for Trial ID: ISRCTN42984928

Or CPMS 64836

Last updated 06 December 2024

This page is to help you find out about a research study and if you may be able to take part

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