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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Dr
Claire
McDonald
claire.mcdonald@ncl.ac.uk
Dr
Claire
McDonald
claire.mcdonald@ncl.ac.uk
Disorders of musclesMood [affective] disordersGeneral symptoms and signs
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The number of people living with multiple long-term conditions (MLTC) is increasing. MLTC becomes more common as we age. Ageing is associated with increased inflammation, damage to our cells and DNA causing our cells to work less effectively. These age related biological changes have also been associated with MLTC.
Both ageing and MLTC have been associated with loss of muscle strength, fatigue, depressive symptoms, and decreased activity. We suspect that these symptoms may be linked to biological changes commonly associated with ageing. Reduced physical activity may further exacerbate progression of MLTC. Conversely increased activity may have protective effects, potentially by modifying these age related biological changes.
Previous studies have looked at these symptoms in isolation or focused on how social factors may explain complex connections. This study aims to better understand the shared underlying biological mechanisms between muscle strength, fatigue, depressive symptoms and activity in MLTC.
We aim to recruit 60 people from the MULTIPLE Registry – a database of people living with MLTC who have expressed an interest in taking part in research. We will assess participants, mood, levels of fatigue, muscle strength, endurance, muscle size and measure physical using a small sensor attached to the lower back. We will collect blood samples to measure a series of blood tests that are markers of biological ageing.
This study will help us to begin to understand the connections between biological ageing and the common symptoms of fatigue, low mood, and loss of strength in people with MLTC, in turn helping to identify potential targets for treatments to improve muscle strength, fatigue and mood all with a single treatment. This would help many people with MLTC to stay healthy and active for longer, without the burden of taking multiple different medications for each condition.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Cross-sectional;
You can take part if:
You may not be able to take part if:
- Unable to give written informed consent - Individuals participating in an interventional trial/study or have done so within the last 30 days. Individuals will be able to enrol in the study after this period of time has elapsed however. (Individuals who are enrolled in an observational study can enter the study without this restriction). - Not resident within the catchment area of a participating site - Individuals not willing are unable to undergo phlebotomy. - Individuals unable to complete questionnaires in English a validated language
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
The study is sponsored by THE NEWCASTLE UPON TYNE HOSPITALS NHS FOUNDATION TRUST and funded by NIHR Newcastle Biomedical Research Centre .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 64341
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