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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Seagen Pfizer CT.gov Call Center 1-800-718-1021
ClinicalTrials.gov_Inquiries@pfizer.com


Study Location:

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Be Part of Research - Trial Details - A Safety Study of PF-08046045/SGN-35T in Adults With Advanced Cancers

A Safety Study of PF-08046045/SGN-35T in Adults With Advanced Cancers

Recruiting

Open to: ALL

Age: 18.0 - N/A

Medical Conditions

Lymphoma
Hodgkin Disease
Lymphoma, Non-Hodgkin
Lymphoma, Large B-Cell, Diffuse
Lymphoma, T-Cell
Lymphoma, T-Cell, Cutaneous
Lymphoma, T-Cell, Peripheral
Lymphoma, Large-Cell, Anaplastic


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


This clinical trial is studying lymphoma. Lymphoma is a cancer that starts in the blood cells that fight infections. There are several types of lymphoma. This study will enroll people who have lymphoma, such as classical Hodgkin lymphoma, peripheral T-cell lymphoma including systemic anaplastic large cell lymphoma, diffuse large B-cell lymphoma, or some types of primary cutaneous lymphoma.

This clinical trial uses a drug called PF-08046045/SGN-35T. The study drug is in testing and has not been approved for sale. This is the first time PF-08046045 will be used in people. The study drug will be given as an infusion through a vein.

This study will test the safety of PF-08046045 in participants with lymphoma. It will also study the side effects of this drug. A side effect is anything a drug does to the body besides treating the disease.

This study will have three parts. Parts A and B of the study will find out the best dose and dosing schedule for PF-08046045. Part C will use the dose found in parts A and B to find out how safe PF-08046045 is and if it works to treat select lymphomas.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Feb 2024 Jun 2028

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Given into the vein (IV; intravenously)

Intervention Arm Group : PF-08046045;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • The Royal Marsden NHS Foundation Trust
    London
    SW3 6JJ
  • University College London Hospital NHS Foundation Trust
    London
    NW1 2BU
  • Cancer and Haematology Centre
    Oxford
    OX3 7LE
  • NIHR UCLH Clinical Research Facility
    London
    W1T 7HA
  • Royal Marsden Hospital, Pharmacy Stores
    Sutton
    Surrey
    SM2 5PT
  • Clinical Trials Aseptic Unit (CTASU) Churchill Hospital
    Oxford
    OX3 7LE
  • University College London Hospitals NHS Foundation Trust
    London
    NW1 2BU

Seagen Pfizer CT.gov Call Center 1-800-718-1021
ClinicalTrials.gov_Inquiries@pfizer.com



The study is sponsored by Seagen, a wholly owned subsidiary of Pfizer




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Read full details for Trial ID: NCT06120504
Last updated 10 July 2025

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