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Contact Information:

Increase Akinyemi +447731513982
i.akinyemi@imperial.ac.uk


Hashim Ahmed +44 (0)20 7594 1660
hashim.ahmed@imperial.ac.uk


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Be Part of Research - Trial Details - Imperial Prostate 9 - ATLAS (Approaches To Long-Term Active Surveillance)
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Imperial Prostate 9 - ATLAS (Approaches To Long-Term Active Surveillance)

Recruiting

Open to: MALE

Age: 18.0 - N/A

London Dartford Ascot

Medical Conditions

Prostatic Neoplasms

This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The goal of this intervention study is for patients on active surveillance for prostate cancer, to demonstrate that use of regular MRI scans is better able to detect cancer progression over 5 years compared to the current NICE defined strategy.

Research Question P - In patients who are on active surveillance for low to medium risk prostate cancer, I - is the use of regular MRI scans C - compared to current NICE defined standard of care, O - better at detecting cancer progression with less cost to the NHS (fewer PSA tests, biopsies and clinic visits)?

Patients will be allocated in a 1.1 ratio to either MRI scans or the current NICE defined standard. Randomisation will be blocked (random block size) and stratified by MRI visibility of lesions (3 categories \[ no visible lesion, diffuse changes, discrete visible lesion\]), cancer Grade Group (GG1, GG2) and time since diagnosis. This study will not be blinded to patients or physicians.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

May 2024 Jun 2029

INTERVENTIONAL

Intervention Type : DIAGNOSTIC_TEST
Intervention Description : The regular use of MRI in active surveillance will lead to greater confidence in active surveillance for patients with low and medium risk prostate cancer. This is because such a strategy is likely to detect cancer progression earlier with fewer invasive biopsies. Those patients randomised to the intervention arm will have additional MRI scans. These will be non-contrast so there is no risk from having repeated 1-2 yearly injections of gadolinium contrast. Patients with contraindications to MRI will not be taking part in the study so will not be exposed to an unnecessary MRI.

Patients with a visible lesion or medium risk cancer will have PSA 6 monthly and MRI annually. All other patients will undergo PSA 6 monthly and MRI in years 1, 3 and 5. In all patients, a targeted biopsy will be carried out if the MRI PRECISE score is \>/=4.

Intervention Arm Group : Intervention Arm;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Charing Cross Hospital
    London
    W6 8RF
  • Darent Valley Hospital
    Dartford
    Kent
    DA2 8DA
  • Heatherwood Hospital
    Ascot
    Berkshire
    SL5 7GB

Hashim Ahmed +44 (0)20 7594 1660
hashim.ahmed@imperial.ac.uk


Increase Akinyemi +447731513982
i.akinyemi@imperial.ac.uk



The study is sponsored by Imperial College London and is in collaboration with Queen Mary University of London; University of Leeds; University College, London; University of York; University College London Hospitals.




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Read full details for Trial ID: NCT06280781
Last updated 22 January 2025

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