Ask to take part

Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Prof Barney Dunn
776613221
b.d.dunn@exeter.ac.uk


Study Location:

Skip to Main Content
English | Cymraeg
Be Part of Research - Trial Details - ADepT for hard-to-treat depression

ADepT for hard-to-treat depression

Recruiting

Open to: All Genders

Age: Adult

Medical Conditions

Depression


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


Depression is common, causes significant distress, and makes it hard to have a sense of well-being and function fully in everyday life. Current talking treatments do not work for everyone; many who finish NHS Talking Therapies treatment options still suffer from symptoms of depression and are still considered as experiencing depression by services. This highlights the need to develop and evaluate new approaches, particularly for those who still have symptoms of depression after NHS Talking Therapy treatments. People with depression experience more negative emotions and thoughts, and experience fewer positive emotions and thoughts including feeling content and experiencing wellbeing. Both need to improve if people are to fully recover. Current talking treatments are useful in repairing negative emotions but are less good at rebuilding positive emotions. Augmented Depression Therapy (ADepT) was co-designed with people with lived experience of depression with an equal focus on building positivity (including building well-being) and reducing negativity (such as having negative thoughts). Previous work shows that ADepT successfully reduces negative emotions and builds positive emotions in adults with depression, leading to reductions in the symptoms of depression as well as large increases in well-being. This research will begin to evaluate if ADepT can also help those who are still depressed after attempting NHS Talking Therapies treatment options for depression (characterised as scoring at least 10 on a routinely administered measure of depression in NHS Talking Therapies called the PHQ-9, after completing 10 or more sessions). Up to fifteen adults suffering from depression will be offered ADepT at the AccEPT clinic, Devon. This study will evaluate if it is effective using a ‘case series’ methodology, tracking changes in depression and anxiety symptoms and well-being in the weeks before, during and after treatment. People who received ADepT will be invited to take part in an interview to discuss their experiences of treatment.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

24 Oct 2023 24 Oct 2025

Participants will receive up to 15 weekly acute sessions and up to five booster sessions in the year after acute treatment has finished of ADepT. To evaluate ADepT, participants will be asked to fill out a short series of questionnaire measures weekly before, during and two months after therapy. They will also be asked to fill in a longer series of measures before, after, two months after and one year after completing treatment and to take part in an interview exploring their views of treatment.


Adults suffering from depression who are still unwell after receiving at least 10 sessions of high-intensity therapy for depression in Devon NHS Talking Therapies services in the past six months.

You can take part if:



You may not be able to take part if:


1. Currently receiving other psychosocial therapies2. Individuals who are eligible for, would be seen by, or their needs would be best met by secondary care services3. Presenting with another area of difficulty that the therapist and/or client believe should be the primary focus of the current intervention4. Current/past history of schizophrenia or bipolar disorder5. Displaying marked risk to self (self-harm or suicide) or others that the clinician judges could not be managed safely using weekly therapy in an out-patient setting and that would interfere with engagement in therapy6. Presenting with features of substance misuse, problematic eating, and/or personality difficulties that the clinician judges could not be managed safely using weekly therapy in an out-patient setting and that would interfere with engagement in therapy7. Presenting with features of a learning disability that the clinician judges would interfere with engagement in therapy and capacity to complete research assessments 8. Currently lacking capacity to give informed consent9. Presenting with any other significant, severe or life-threatening disease, disorder, or cognitive impairment that the clinician judges may either put the participants at risk because of participation in the study, may influence the result of the study, or inhibit the participant’s ability to participate in the study


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • AccEPT clinic
    Mood Disorders Centre, University of Exeter
    Exeter
    ex44qq

Participants will receive psychological therapy which is anticipated to improve depression, anxiety and wellbeing. Participants will be asked to fill in various questionnaires and take part in interviews, which for some people at times temporarily lower their mood.

Where is the study run from?
The study is run from the AccEPT clinic, Mood Disorders Centre, University of Exeter

Prof Barney Dunn
776613221
b.d.dunn@exeter.ac.uk



The study is sponsored by University of Exeter and funded by NIHR Oxford Biomedical Research Centre.




We'd like your feedback

Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.


Is this study information helpful?

What will you do next?

Read full details for Trial ID: ISRCTN13823401
Last updated 07 October 2024

This page is to help you find out about a research study and if you may be able to take part

You can print or share the study information with your GP/healthcare provider or contact the research team directly.