Ask to take part

Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Dr Lyn Jones
+44 (0)1174149330
Lyn.Jones@nbt.nhs.uk


More information about this study, what is involved and how to take part can be found on the study website.

Study Location:

Find another location


Questions to ask
Skip to Main Content
English | Cymraeg
Be Part of Research - Trial Details - Testing whether a fast MRI scan can detect breast cancers which were not detected on mammograms, in women with average breast density
Back

Testing whether a fast MRI scan can detect breast cancers which were not detected on mammograms, in women with average breast density

Recruiting

Open to: Female

Age: Adult

Bristol London Cheltenham Truro Swindon London

Medical Conditions

To measure the number of cancers detected by FAST MRI that were missed by screening mammography

This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


Early detection of breast cancer saves lives. The NHS Breast Screening Programme (NHSBSP) currently uses mammograms (quick X-rays) to look for signs of breast cancer. While mammograms are fast and widely used, they can sometimes miss small, aggressive cancers. MRI scans are better at spotting these cancers but take longer and cost more, so they’re usually only offered to people at a very high risk.

A newer scan called FAST MRI is quicker than a standard MRI and may be better than mammograms at finding small, aggressive cancers. So far, research has focused only on women with high breast density. This study, called DYAMOND, will test whether FAST MRI can help detect cancers in women with average breast density who haven’t been included in previous studies.

If FAST MRI proves helpful for this group, it could lead to a larger study and potentially change how breast screening is done in the future.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

22 May 2025 31 Jul 2026

Publications

2025 Protocol article in https://pubmed.ncbi.nlm.nih.gov/41022446/ (added 30/09/2025)

Stage 1
If participants consent to Stage 1, the research team will send their mammograms to the Royal Surrey NHS Trust to be analysed for breast density. The team will also check their screening records to see if their mammogram was clear. They will then be contacted by letter or by telephone to let them know if they can enter Stage 2 and have a FAST MRI scan.

Stage 2
All DYAMOND participants who consent to Stage 2 will have a FAST MRI as well as their standard screening mammogram. Some participants will have a second FAST MRI 1 year later.

Trained health professionals will check the FAST MRI images. If any cancers are found, the women will be looked after by their local hospital, which will collect information about their care for the DYAMOND study team. Women will be asked their thoughts about having the FAST MRI scan to understand their experiences.


Stage 1 – Women aged 50 to 52, attending their first NHS breast screening mammogram, who do not have breast implants.
Stage 2 – Women who agreed to stage 1 may be invited to have a FAST MRI scan if their mammogram shows average breast density (called BI-RADS B) and a Routine Recall letter is received.

You can take part if:



You may not be able to take part if:


Current key exclusion criteria as of 17/09/2025:Stage 1 Consent (Breast Density Measurement):1. Has not received a mammogram within the NHSBSP2. Aged [<49 years + 8 months] or ≥ 53 years at time of mammogram (source: NBSS)3. Unwilling to have mammograms measured for density4. Unwilling or unable to give informed consent to Stage 15. Breast implants

Stage 2 Consent (FAST MRI DYAMOND scan):1. Breast density category A, C or D or if not determined (source: RSNFT)2. Known recall after mammogram (source: NBSS)3. Pregnant or breastfeeding4. Contraindication to MRI5. Contraindication to gadolinium-containing contrast agents (GDCA)6. Unwilling to have FAST MRI7. Unwilling to allow follow-up of outcomes through data linkage8. Estimated glomerular filtration rate (eGFR) equal to or below 30 (participant reported)9. BMI, weight and abdominal girth restrictions may apply to recruiting sites’ MRI scanner(s) that could exclude otherwise eligible participants from having the study intervention.



Previous key exclusion criteria:1. Breast density category A, C or D2. Known recall after mammogram3. Has not received a breast mammogram4. Aged [< 49 years + 8 months] or > = 53 years at time of mammogram 5. Pregnant or breastfeeding6. Contraindication to MRI7. Contraindication to gadolinium-containing contrast agents (GDCA)8. Unwilling to have FAST MRI9. Unwilling to allow follow-up of outcomes through data linkage 10. Unwilling to have mammograms measured for density11. eGFR equal to or below 3012. BMI, weight and abdominal girth restrictions may apply to recruiting sites’ MRI scanner(s) that could exclude otherwise eligible participants from having the study intervention


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Southmead Hospital
    Southmead Road Westbury-on-trym
    Bristol
    BS10 5NB
  • St Georges Hospital
    Blackshaw Road Tooting
    London
    SW17 0QT
  • Cheltenham General Hospital
    Sandford Road
    Cheltenham
    GL53 7AN
  • Royal Cornwall Hospital (treliske)
    Treliske
    Truro
    TR1 3LJ
  • Great Western Hospital
    Marlborough Road
    Swindon
    SN3 6BB
  • Kings College Hospitals
    Denmark Hill
    London
    SE5 9RS

Benefits: The FAST MRI scan may find breast cancer earlier than it would have been found without the DYAMOND study. Treatments are more effective when a cancer is detected early, and so the cancer may be more likely to be cured.
Risks: To have a FAST MRI, participants will need to have an injection into a vein in their arm at the time of the scan. Hospitals worldwide use this type of injection every day for standard MRI scans of many different parts of the body. The MRI radiographers will follow all standard safety procedures for the injection and the scan during DYAMOND.

Dr Lyn Jones
+44 (0)1174149330
Lyn.Jones@nbt.nhs.uk



More information about this study, what is involved and how to take part can be found on the study website.


The study is sponsored by North Bristol NHS Trust and funded by National Institute for Health and Care Research; Medical Research Council.



We'd like your feedback

Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.


Is this study information helpful?

What will you do next?
Read full details for Trial ID: ISRCTN74193022

Or CPMS 59828

Last updated 06 October 2025

This page is to help you find out about a research study and if you may be able to take part

You can print or share the study information with your GP/healthcare provider or contact the research team directly.   

Back to the top