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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Dr Lyn Jones
+44 (0)1174149330
Lyn.Jones@nbt.nhs.uk


More information about this study, what is involved and how to take part can be found on the study website.

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Be Part of Research - Trial Details - Testing whether a fast MRI scan can detect breast cancers which were not detected on mammograms, in women with average breast density
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Testing whether a fast MRI scan can detect breast cancers which were not detected on mammograms, in women with average breast density

Recruiting

Open to: Male

Age: Adult

London Cheltenham Truro Swindon London

Medical Conditions

To measure the number of cancers detected by FAST MRI that were missed by screening mammography

This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


Finding breast cancers early saves lives. The NHS Breast Screening Programme (NHSBSP) uses either mammograms (quick X-rays) or magnetic resonance imaging (MRI) scans to find breast cancers as early as possible. Mammograms are used most widely as they are quick but are less good at finding the most aggressive cancers early. MRIs are better at detecting small aggressive cancers but take longer and are expensive, so are only offered to people at the highest risk of getting breast cancer. A newer type of scan is the “FAST” MRI scan. This is quicker than standard MRI and may be better at detecting small cancers than mammograms. Until now, researchers worldwide have focussed on women with high breast density to test if FAST MRI can find breast cancers early. This means that, until now, women with average breast density have been unable to take part in research about FAST MRI. The DYAMOND study will test if a FAST MRI can detect cancers not seen on a first screening mammogram, for women with average-density breasts. If this study shows that cancers not found by a mammogram can be found by FAST MRI for women with average-density breasts, this group of women will be included in a larger study to see if FAST MRI is a good alternative to mammograms for breast screening.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

25 Oct 2024 30 Sep 2025

All DYAMOND participants will have a FAST MRI as well as their standard screening mammogram. Some participants will have a second FAST MRI 1 year later.
Trained health professionals will check the FAST MRI images. If any cancers are found, the women will be looked after by their local hospital, which will collect information about their care for the DYAMOND study team. Women will be asked their thoughts about having the FAST MRI scan to understand their experiences.


Women will be invited for a FAST MRI if they are aged 50-52 years old, their mammogram does not show cancer and their breast density is “average” (a computer measures this from mammogram images).

You can take part if:



You may not be able to take part if:


1. Breast density category A, C or D2. Known recall after mammogram3. Has not received a breast mammogram4. Aged [< 49 years + 8 months] or > = 53 years at time of mammogram 5. Pregnant or breastfeeding6. Contraindication to MRI7. Contraindication to gadolinium-containing contrast agents (GDCA)8. Unwilling to have FAST MRI9. Unwilling to allow follow-up of outcomes through data-linkage 10. Unwilling to have mammograms measured for density11. eGFR equal to or below 3012. BMI, weight and abdominal girth restrictions may apply to recruiting sites’ MRI scanner(s) that could exclude otherwise eligible participants from having the study intervention


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • St Georges Hospital
    Blackshaw Road Tooting
    London
    SW17 0QT
  • Cheltenham General Hospital
    Sandford Road
    Cheltenham
    GL53 7AN
  • Royal Cornwall Hospital (treliske)
    Treliske
    Truro
    TR1 3LJ
  • Great Western Hospital
    Marlborough Road
    Swindon
    SN3 6BB
  • Kings College Hospitals
    Denmark Hill
    London
    SE5 9RS

Benefits: The FAST MRI scan may find breast cancer earlier than it would have been found without the DYAMOND study. Treatments are more effective when a cancer is detected early and so this could prevent the participant from dying from their breast cancer.
Risks: To have a FAST MRI, participants will need to have an injection into a vein in their arm at the time of the scan. Hospitals worldwide use this type of injection every day for standard MRI scans of many different parts of the body. The MRI radiographers will follow all standard safety procedures for the injection and the scan during DYAMOND.

Dr Lyn Jones
+44 (0)1174149330
Lyn.Jones@nbt.nhs.uk



More information about this study, what is involved and how to take part can be found on the study website.


The study is sponsored by North Bristol NHS Trust and funded by National Institute for Health and Care Research; Medical Research Council.



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Read full details for Trial ID: ISRCTN74193022

Or CPMS 59828

Last updated 25 October 2024

This page is to help you find out about a research study and if you may be able to take part

You can print or share the study information with your GP/healthcare provider or contact the research team directly.   

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