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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Benjamin
Bussmann
ben.bussmann@ouh.nhs.uk
Dr
Kim
Dora
kim.dora@pharm.ox.ac.uk
Neil
Herring
Neil.herring@dpag.ox.ac.uk
Chronic rheumatic heart diseasesIschaemic heart diseasesOther forms of heart disease
This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.
Blood flow to the heart muscle is normally regulated by microscopic arteries in the heart. To control
the blood flow, these microscopic arteries are able to change their size, thus either increasing or
reducing blood flow to meet the demands of the heart. In many people these microscopic arteries
are dysfunctional, called “microvascular dysfunction”, leading to symptoms and worse heart
outcomes. In patients it is possible to estimate the function of these microscopic heart arteries
during an angiogram procedure using specialised wires inserted into the heart. However, this does
not give any information about the underlying cause of dysfunction. Indeed, very little is known
about the mechanisms that leading to microvascular dysfunction despite this being a common
condition.
This research study is designed to investigate the causes of microvascular dysfunction. It is
possible to isolate microscopic heart arteries from excess heart muscle left over after open heart
surgery, and then directly measure their function in a laboratory. In this way we can better
understand how their function is related to factors such as co-existing medical conditions or
biomarkers in the blood. A better understanding of how microscopic heart arteries function and
what causes them to dysfunction will enable us to develop new therapies and tests to diagnose and
treat patients with microvascular dysfunction.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Validation of investigation /therapeutic procedures;
You can take part if:
You may not be able to take part if:
Severe epicardial coronary artery disease which prevents accurate assessment of microvascular function Pregnancy confirmed in medical records or detected as part of routine screening before surgery or as part of Ionising Radiation (Medical Exposure) Regulations (IRMER). HIV, Hepatitis A, B or C infection confirmed in the patient’s available medical records. Patients who have a history / current diagnosis of cancer or who have received / are receiving chemotherapy or radiotherapy. Any impediment to communication which, in the opinion of the investigator, might prevent the investigator communicating effectively with the patient during the study (including inability to speak English).
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
Neil
Herring
Neil.herring@dpag.ox.ac.uk
Dr
Kim
Dora
kim.dora@pharm.ox.ac.uk
Benjamin
Bussmann
ben.bussmann@ouh.nhs.uk
The study is sponsored by University of Oxford and funded by BRITISH HEART FOUNDATION; BRITISH HEART FOUNDATION; .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 62422
You can print or share the study information with your GP/healthcare provider or contact the research team directly.
