Ask to take part

Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Mrs Ann Doust
ann.doust@ed.ac.uk


More information about this study, what is involved and how to take part can be found on the study website.

Study Location:

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Be Part of Research - Trial Details - ESPriT2 – a multicentre clinical trial to determine whether surgical removal of superficial peritoneal endometriosis improves pain symptoms and quality of life

ESPriT2 – a multicentre clinical trial to determine whether surgical removal of superficial peritoneal endometriosis improves pain symptoms and quality of life

Medical Conditions

Women with isolated superficial peritoneal endometriosis


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


Endometriosis is a chronic, incurable condition that affects about 10% of women of reproductive age. It is defined as a growth of cells similar to the womb lining outside of the womb in the pelvis, and is associated with chronic pelvic pain,excessive period pain, pain with sexual intercourse and difficulties in getting pregnant. If the disease is found only on the lining of the pelvis it is known as “superficial peritoneal endometriosis” and is usually treated during a laparoscopic surgery by cutting out (excision) or burning off (ablation). However, many women do not find improvement in their symptoms after the surgery and can have complications from the procedure. The aim of this study is to determine if removal of the superficial peritoneal endometriosis improves pain symptoms and quality of life, which method of removal (excision or ablation) is more effective or if surgical removal is of no benefit to the patients and can potentially cause harm.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

05 May 2021 28 Feb 2025

Publications

2023 Protocol article in https://pubmed.ncbi.nlm.nih.gov/37349849/ (added 23/06/2023)

Patients who consent to the trial will be randomised during the surgery, if superficial endometriosis is found, to either having the endometriosis removed or not. Follow-up will be at 30 days, 3, 6 months and 12 month post-operatively. We will also carry out a data linkage follow-up of up to 5 years.


Women who are attending gynaecology departments with pelvic pain who have not previously had a diagnosis of endometriosis via laparoscopy.

You can take part if:



You may not be able to take part if:


1. Previous surgical diagnosis of endometriosis2. Pregnant 3. Women who have undergone hysterectomy and or bilateral oophorectomy4. Deep endometriosis on imaging or at time of laparoscopy5. Ovarian cyst on imaging that is the indication for surgery6. Ovarian cyst requiring surgical management at time of laparoscopy7. Dense adhesions that require surgical management at time of laparoscopy8. Peritoneal ‘pockets’ only noted at laparoscopy9. Endometrioma observed at the time of laparoscopy


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Royal Infirmary of Edinburgh
    NHS Lothian 51 Little France Crescent
    Edinburgh
    EH16 4SA
  • Guy's and St Thomas' NHS Foundation Trust
    Westminster Bridge Road
    London
    SE1 7EH
  • Derriford Hospital
    University Hospitals Plymouth NHS Trust Derriford Road
    PLYMOUTH
    PL6 8DH
  • John Radcliffe Hospital
    Oxford University Hospitals NHS Foundation Trust Headley Way
    Oxford
    OX3 9DU
  • Victoria Hospital
    NHS Fife
    Kirkcaldy
    KY2 5AH
  • Countess of Chester Hospital
    Countess of Chester Hospital NHS Foundation Trust
    Chester
    CH2 1UL
  • Queen Alexandra Hospital
    Portsmouth Hospitals University NHS Trust Cosham
    Portsmouth
    PO6 3LY
  • Aberdeen Infirmary
    NHS Grampian Foresterhill
    Aberdeen
    AB25 2ZN
  • University Hospital Crosshouse
    NHS Ayrshire and Arran Crosshouse
    Kilmarnock
    KA2 0BE
  • Forth Valley Hospital
    NHS Forth Valley Stirling Road
    Larbet
    FK5 5WR
  • City Hospital
    SWB NHS Trust Dudley Road
    Birmingham
    B18 7QH
  • Birmingham Women's Hospital
    Birmingham Women's and Children's NHS FT Mindelsohn Way Edgbaston
    Birmingham
    B15 2TG
  • Princess of Wales Hospital
    Cwm Taf Morgannwg UHB Coity Road
    Bridgend
    CF31 1RQ
  • Burnley General Hospital
    East Lancashire NHS Teaching Trust Casterton Avenue
    Burnley
    BB10 2PQ
  • Addenbrooke's Hospital
    Cambridge University Hospital NHS Foundation Trust Hills Road
    Cambridge
    CB2 0QQ
  • St Mary's Hospital
    Manchester University NHS Foundation Trust Oxford Road
    Manchester
    M13 9WL
  • North Devon District Hospital
    Royal Devon and Exeter NHS Foundation Trust Raleigh Heights
    Barnstaple
    EX31 4JB
  • University Hospitals Dorset
    Longfleet Road
    Poole
    BH15 2JB
  • Rotherham Hospital
    The Rotherham NHS Foundation Trust Moorgate Road
    Rotherham
    S60 2UD
  • Royal Cornwall Hosptial
    Royal Cornwall Hospitals NHS Trust Treliske
    Truro
    TR1 3LJ
  • Princess Anne Hospital
    University of Southampton NHS Coxford Road
    Southampton
    SO16 5YA
  • Southend University Hospital
    Southend University Hospital NHS Foundation Trust Prittlewell Chase Westcliff-on-Sea
    Southend-on-Sea
    SS0 0RY
  • James Cook Hospital
    South Tees NHS Trust
    Middlesbrough
    TS4 3BW
  • South Tyneside District Hospital
    South Tyneside and Sunderland Foundation Trust
    South Shields
    NE34 0PL
  • Stoke Mandeville Hospital
    Bucks Healthcare NHS Trust
    Aylesbury
    HP218AL
  • Princess Royal Hospital
    Shrewsbury and Telford Hospitals NHS Trust
    Telford
    TF1 6TF
  • University College London Hospital
    University College London Hospitals NHS Foundation Trust Gynaecology Unit Lower Ground Floor EGA Wing 235 Euston Road
    London
    NW1 2BU
  • Manor Hospital
    Walsall Healthcare NHS Trust Moat Road
    Walsall,
    WS2 9PS
  • West Middlesex University Hospital
    West Middlesex University Hospital, Chelsea and Westminster Hospital NHS Foundation Trust Twickenham Road Isleworth
    London
    TW7 6AF
  • Yeovil District Hospital
    Yeovil District Hospital NHS Foundation Trust Higher Kingston
    Yeovil
    TA19 0BE

Participants may or may not get a direct benefit from taking part in this trial. This trial will generate information to allow women with suspected endometriosis and gynaecologists to make an informed choice whether to immediately remove endometriosis when a diagnostic laparoscopy identifies superficial peritoneal endometriosis alone. If the trial shows that removal of superficial peritoneal endometriosis does not help, or makes symptoms worse, this would mean that women could choose to not have it removed or avoid a diagnostic laparoscopy altogether. Women could then opt for early pain management with painkillers, hormones and drugs that work on the nerves in the pelvis.

Mrs Ann Doust
ann.doust@ed.ac.uk



More information about this study, what is involved and how to take part can be found on the study website.


The study is sponsored by University of Edinburgh; NHS Lothian and funded by National Institute for Health Research.




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Read full details for Trial ID: ISRCTN27244948

Or CPMS 48838

Last updated 06 November 2024

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