Ask to take part

Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Michael Sun, M.S. michael.sun@dualitybiologics.com


Helen Liu 86-21-26018730
helen.liu@dualitybiologics.com


Study Location:

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Be Part of Research - Trial Details - A Study of DB-1303/BNT323 vs Investigator's Choice Chemotherapy in HER2-Low, Hormone Receptor Positive Metastatic Breast Cancer (DYNASTY-Breast02)

A Study of DB-1303/BNT323 vs Investigator's Choice Chemotherapy in HER2-Low, Hormone Receptor Positive Metastatic Breast Cancer (DYNASTY-Breast02)

Recruiting

Open to: ALL

Age: 18.0 - N/A

Medical Conditions

Breast Neoplasms


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The goal of this clinical trial is to assess the efficacy of DB-1303/BNT323 compared with investigator's choice chemotherapy in terms of progression-free survival (PFS) by blinded independent central review (BICR) in the HR+, HER2-low (immunohistochemistry \[IHC\]2+/in situ hybridization \[ISH\]- and IHC 1+) population.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Jan 2024 May 2026

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : IV

Intervention Arm Group : DB-1303/BNT323;

Intervention Type : DRUG
Intervention Description : Oral

Intervention Arm Group : investigator's choice single agent chemotherapy;

Intervention Type : DRUG
Intervention Description : IV

Intervention Arm Group : investigator's choice single agent chemotherapy;

Intervention Type : DRUG
Intervention Description : IV

Intervention Arm Group : investigator's choice single agent chemotherapy;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Research Site 4404-0
    Truro
    Cornwall
    TR1 3LJ
  • Research Site 4408-0
    London
    Greater London
    EC1A 7BE
  • Research Site 4409-0
    London
    Greater London
    W1G 6AD
  • Research Site 4402-0
    Manchester
    Greater Manchester
    M20 4BX
  • Research Site 4407-0
    Leeds
    West Yorkshire
    LS9 7TF
  • Research Site 4401-0
    Nottingham
    NG5 1PB


The study is sponsored by DualityBio Inc. and is in collaboration with BioNTech SE.





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Read full details for Trial ID: NCT06018337
Last updated 27 February 2025

This page is to help you find out about a research study and if you may be able to take part

You can print or share the study information with your GP/healthcare provider or contact the research team directly.