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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Jenny
King
Jenny.king@manchester.ac.uk
Prof
jaclyn
Smith
jacky.smith@manchester.ac.uk
Acute upper respiratory infectionsChronic lower respiratory diseasesOther acute lower respiratory infectionsOther diseases of upper respiratory tract
This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.
This study is looking at what causes cough in different lung diseases including chronic cough,asthma,copd and interstitial lung disease. People undergo 4 different nebuliser tests designed to activate different airway nerves. By looking at patterns of cough response we can identify new potential treatment targets.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Cross-sectional;
You can take part if:
You may not be able to take part if:
General • Ex-smokers with <6 months abstinence • Upper respiratory tract infection within last 4 weeks • Patients with severe respiratory disease e.g. FEV1 <1 litre,requirement of oxygen therapy • Use of ACE inhibitors • Use of centrally acting medications that may alter the cough reflex e.g. opiates,gabapentin,pregabalin,amitriptyline* • History of drug or alcohol abuse • Pregnancy or breastfeeding • Concomitant conditions which may alter cough responses e.g. diabetes mellitus with autonomic neuropathy,Parkinson’s disease,stroke. • Concomitant conditions which affect the subjects’ ability to participate in the study. • Uncontrolled hypertension (i.e.,>165/95 mmHg despite adequate medical therapy). • Allergy or intolerance of salbutamol *Any participant who is taking these medications as a treatment for their cough will not be eligible to take part in this study unless they are willing and medically able to withdraw from such medication for the duration of the study and sought advice from their GP or clinician. Those on such medication for other clinical reasons (e.g. chronic pain) may be considered for the study. Asthma • Subjects treated with high dose inhaled corticosteroid (>250mcg fluticasone propionate daily or equivalent) • A change in regular asthma medication within the past 4 weeks prior to screening Exacerbation of respiratory disease in the last 4 weeks requiring additional medication. Idiopathic Pulmonary Fibrosis • High dose systemic steroids i.e. prednisolone >20mg daily or equivalent. Those patients on lower doses of steroids for >1 month may be included • A change in regular medication for IPF within the past 4 weeks prior to screening • Resting blood oxygen saturation of <90 % • Concurrent use of pirfenidone,unless receiving a stable dose for at least 4 weeks prior to screening • A history of concomitant asthma or obstructive airway disease,or those with an FEV1/FVC ratio at screening of <70% • Exacerbation of respiratory disease in the last 4 weeks requiring additional medication. COPD • A change in regular medication for COPD within the past 4 weeks prior to screening • Exacerbation of respiratory disease in the last 4 weeks requiring additional medication
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
The study is sponsored by MANCHESTER UNIVERSITY NHS FOUNDATION TRUST and funded by Wellcome Trust .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 63268
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