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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Seline
Uran
scu24@bath.ac.uk
Seline
Uran
scu24@bath.ac.uk
Katherine
Button
kb658@bath.ac.uk
Mood [affective] disorders
This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.
The purpose of this study is to measure changes in brain activity and track fluctuations in mood and symptoms throughout the course of antidepressant withdrawal. We will also study the relationship between mood and social interactions using daily surveys administered via a smartphone app. We hope to determine whether neural activity, mood or withdrawal symptoms can be used to predict relapse 6 months after beginning withdrawal.
This is an observational 6-month follow-up study that will involve repeated testing of individuals who have been taking antidepressants for at least 6 months but are not depressed and thus feel well enough to come off them. They will be asked to participate in a total of 4 sessions; three will be in person (Baseline, 1 month follow up and 3 month follow up) whereas the final session will be online (6 months follow up). At each session they will be asked to complete some questionnaires and cognitive tasks whilst their brain activity is measured using electroencephalography (EEG). EEG is a safe, non-invasive brain imaging technique that involves placing a cap with sensors over the head and measuring the weak electrical signals emitted by the brain.
It is hoped that the data gathered in this study will be useful in helping GPs to manage the process of antidepressant withdrawal and inform patients of the likely time course of any mood changes or withdrawal symptoms that they may experience during withdrawal. This research also has the potential to help identify which factors are important in predicting depressive relapse. It is hoped that this data will be useful in helping GPs to manage the process of antidepressant withdrawal.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Cohort study;
You can take part if:
You may not be able to take part if:
- Is not fluent in written and spoken English. - Does not have normal or corrected to normal vision. - Suffers from epilepsy. - Meet the ICD-11 criteria for depression at baseline (this will be assessed when administering the CIS-R). - Diagnosed with bipolar disorder, schizophrenia, psychosis, dementia, an eating disorder or a substance use disorder. - Currently receiving treatment for substance abuse or regular sessions of psychological therapy for a mood disorder. - Being pregnant
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
The study is sponsored by University of Bath and funded by Medical Research Council (MRC) .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 62332
You can print or share the study information with your GP/healthcare provider or contact the research team directly.
