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Be Part of Research - Trial Details - A Study to Assess Efficacy and Safety of Adjunctive KarXT in Subjects With Inadequately Controlled Symptoms of Schizophrenia

A Study to Assess Efficacy and Safety of Adjunctive KarXT in Subjects With Inadequately Controlled Symptoms of Schizophrenia

Completed

Open to: ALL

Age: 18.0 - 65.0

Medical Conditions

Schizophrenia


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


This is a Phase 3, 6-week, randomized, double-blind, placebo-controlled, multicenter, outpatient study in subjects with schizophrenia with an inadequate response to their current atypical antipsychotic treatment. The primary objective of the study is to assess the efficacy of adjunctive KarXT (a fixed dose combination of xanomeline and trospium chloride twice daily \[BID\]) versus placebo in the treatment of subjects with inadequately controlled symptoms of schizophrenia as measured by the Positive and Negative Syndrome Scale (PANSS) Total Score.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Nov 2021 Mar 2025

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : KarXT 50 mg/20 mg BID KarXT 75mg/20 mg BID KarXT 100mg/20 mg BID KarXT 125mg/30 mg BID

Intervention Arm Group : Drug: KarXT;

Intervention Type : DRUG
Intervention Description : Placebo Capsules

Intervention Arm Group : Placebo;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Local Institution - 705
    Brighton
    East Sussex
    BN1 9RY
  • Local Institution - 708
    Oxford
    Oxfordshire
    OX3 7JX
  • Local Institution - 702
    Chertsey
    Surrey
    KT16 9AU
  • Local Institution - 703
    Birmingham
    West Midlands
    B4 6NH
  • Local Institution - 707
    Pool, Reruth
    Cornwall
    TR15 3QE
  • Local Institution - 701
    London
    Greater London
    SE5 8AF
  • Local Institution - 706
    Ashton Under Lyne
    Greater Manchester
    OL6 7SR
  • Local Institution - 710
    Manchester
    Greater Manchester
    M8 5RB
  • Local Institution - 709
    Maidstone
    Kent
    ME16 9PH
  • Local Institution - 704
    Glasgow
    Strathclyde
    G51 4TF


The study is sponsored by Karuna Therapeutics




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Read full details for Trial ID: NCT05145413
Last updated 25 March 2025

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